Biopolym. Cell. 2006; 22(6):475-479.
http://dx.doi.org/10.7124/bc.00074F
Bioorganic Chemistry
Study of biological activity of some 4-S-derivatives of quinoline
1Gencheva V. I., 1Omelyanchik L. A., 2Fedoryak D. M., 1Brazhko A. A., 1Zavgorodny M. P.
  1. Zaporizhzhya National University
    Zhukovsky Str., 66, Zaporizhzhya, Ukraine, 69600
  2. Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine
    1, Murmans'ka Str., Kyiv, Ukraine, 02094

Abstract

The biological action of (8-methoxy-2-methylquinoline-4-ilthio)-carboxylic acids was studied on the model of acute toxic hepatitis. The most expressed membrane stabilizing effect was observed for p-(8-methoxy-2-methylquinoline-4-ilthio) lactic acid which nor­malizes the level of enzymic activity and protein synthetic function of a liver. The investigated compounds are shown as perspective potential hepatoprotectors
Keywords: 4-S-derivatives of quinoline, membrane stabilizers, hepatoprotectors
Full text: (PDF, in Ukrainian)

References

[1] Medical Statistics of Ukraine: Stat. analyte. directory. K., 2000. 120 p
[2] Kharchenko NV. Comparative characteristics of modern hepatoprotectors. Visn Farmakol ta Farmatsii. 2001:(3-4):18-26.
[3] Pat. 28789 Ukraine, MKI4 C 07 D 215/04, A 61 K 31/435. 2-Methyl-6-methoxy-4-quinolyl thio sodium acetate, which exhibits antioxidant activity and antiischemic. LO. Omelyanchik, OA Brazhko, IF Belenichev, MP Zavgorodniy. Bull. N 8. 6 p.
[4] Pat. 38185 Ukraine, MKI4 C 07 D 215/02. 3- (2-thio- quinoline) - propanoic acid exhibiting antioxidant activity. LO. Omelyanchik, OA Brazhko, IF Belenichev. Bull. N9. 3 p.
[5] Brazhko OA. Biologically active derivatives of quinoline and acridine of nitrogen and sulfur-containing functional groups and: Thesis. ... Dr biol. nauk. K., 2005. 456 p.
[6] Girges MM, Hanna MA, Hassan HM, Moawad EB. Synthesis of some new 3-substituted-4-hydroxy-1-methyl-quinolin-2-one derivatives as potential antibacterial and antifungal agents. Collect Czechoslov Chem Commun. 1988;53(12):3179–83.
[7] Pat. 71883 Ukraine, MKI4 C 07 D 215/02 The sodium salt of b- (6-ethoxy-2-metylhinolin-4) -a- hydroxy propionic acid has antioxidant and hepatoprotective activity. LO. Omelyanchik, OA Brazhko, IF Belenichev, MP Zavgorodniy. Bull. N 12. 8 p.
[8] Poroykov VV. Computer prediction of biologically active substances: the limits of the possible. Khimiia v Rossii. 1999; (2):8—12.
[9] Prozorovskiy VB. Tabular rapid method of determining the average effective interventions on biological objects. Toksikol Vesn. 1998; (1):28-32.
[10] Sidorov KK. The classification of the toxicity of poisons with parenteral route of administration. Toxicology new industrial chemicals. M., 1973; 13: 47—51.
[11] Voloshina ES, Bondarenko LB, Kovalenko VN. Effect of alpha-tocopherol acetate and its derivatives on lipid peroxidation and content of some components of the membranes of the endoplasmic reticulum of liver cells in experimental toxic hepatitis. Sovremen. probl. toksikologii. 1999; (2): 42-4.
[12] Drogovoz SM, Gubskiy YuI, Skakun ML, Kovalenko VM, Vedmid LV. Experimental study of Bile and hepatoprotective effects of new drugs (method recommendations). Ed. OV Stefanov. K. 2001; 334-51.
[13] Laboratory Methods in the clinic: A Handbook. Ed. VV Menshikova. M.: Meditsina, 1987. 360 p.
[14] Lakin GF. Biometrics. Vysshaya Shkola, 1990. 352 p.