Biopolym. Cell. 2006; 22(6):403-424.
http://dx.doi.org/10.7124/bc.000747
Reviews
Molecular biomarkers: new approaches in ovarian cancer diagnosis
1Gordiyuk V. V., 2Simonchuk E. V., 3Kohanevitch E. V., 4Vakulenko G. A., 1, 5Ugryn D. D., 6Manzhura E. P.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. P. L. Shupik National medical academy of post-graduate education
    9, Dorohozhytska Str., Kyiv, Ukraine, 04112
  3. "ISIDA" clinic
    65, Ivana Lepse Boulevard, Kyiv, Ukraine, 03126
  4. Bogomolets National Medical University
    Blvd. Shevchenko, 13, Kyiv, Ukraine, 01601
  5. Taras Shevchenko National University of Kyiv
    64, Volodymyrska Str., Kyiv, Ukraine, 01033
  6. Kiev oncological hospital
    67, Verhovynna Str., Kyiv, Ukraine, 03115

Abstract

The formation of tumors is associated with accumulation of different genetic and epigenetic changes. The current paper summarizes the recent data on molecular markers of human ovarian cancer as well as provides the analysis of the contribution of epigenetic markers for early cancer detection. We examined the significance of changes in signaling pathways in ovarian cancer to identify possible oncomarkers. Monitoring of gene and protein multiple changes has a powerful potential for selection of sets of multiple molecular markers for correct diagnostic and prognostic clinical outcome of ovarian cancer.
Keywords: ovarian tumor, early diagnostic of cancer, epigenetic markers, tumor suppressor, NotI-microchips
Full text: (PDF, in English) (PDF, in Russian)

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