Biopolym. Cell. 2006; 22(4):251-275.
Our «Shagreen leather» is our problem, and we are the ones to solve it. 7. The change of paradigm. First steps
1Kordium V. A.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680


The problem of Timeliness of scientific and technological achievements is brought up for discussion. Existence of more sophisticated mechanisms rather than the real implementation of a new idea, development, and even prototype is being postulated in order for this novelty to enter life and everyday routine. As for our “shagreen leather” problem under consideration, Timeliness is conditioned by Mankind passing into the new system of his existence called the Noosphere. And this fact predetermines the inevitability of its solving. The notion of biological time is analyzed on the grounds of its difference from physical one. The last, though, still not resolved fundamental restriction on the way to the biological time control, i.e. heterochronous incompatibility, is highlighted. The reality of the beginning of the individual’s parting in biological time with his subsequent heterochronous compatibility was also marked to have passed into practice, in the form of cord blood preserving and storing in liquid nitrogen (i.e. at the condition, when the biological time is stopped) with its subsequent usage as autologous material for tissue and organ reconstruction (“regenerative medicine”) for a young, adult and old organism to be. Possible ways of heterochronous material usage and expected establishment of the new “age regulating” trend in medicine are analyzed.
Keywords: biological time, heterochronous compatibility, cord blood


[1] Mechnikov II. Essays of optimism. M.: Nauka, 1988; 328 p.
[2] Zalmanov AS. The secret wisdom of the human organism. St-Peterburg: Nauka, 1991; 329 p.
[3] Kordyum VA. Our shagreen leather is our problem, and we have to solve it. 4. «Shagreenity» that makes our skin shagreen. Biopolym Cell. 2004; 20(4):267-89.
[4] Butenko GM, Gubri? IB. [Primary immune response in parabionts of different ages]. Biull Eksp Biol Med. 1980;89(4):435-7.
[5] Butenko GM. Ageing of the immune system and diseases. Age-related factors in carcinogenesis (IARC Scientific Publ. N 58). New York, 1986: 71-83.
[6] Gubriy IB, Reznikov AG, Demchenko VI, Butenko GM. Suppression of the immune and reproductive systems of young animal when connecting it with the old in parabiosis. Proceedings of Symposium. "Neurohumoral mechanisms of aging" (Kiev, 14-16 Oct 1986, Inst Gerontol AMN SSSR). M.: VINITI, 1986; 33-4.
[7] Butenko GM, Gubri? IB. [Mechanism of immune response inhibition during parabiosis of animals of different ages]. Biull Eksp Biol Med. 1981;92(9):318-9.
[8] Tauchi H, Hasegawa K. Change of the hepatic cells in parabiosis between old and young rats. Mech Ageing Dev. 1977;6(5):333-9.
[9] Uchida K, Takase H, Nomura Y, Satoh T, Igimi H, Takeuchi N. Bile acid metabolism in young-old parabiotic rats. Lipids. 1997;32(4):383-90.
[10] Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature. 2005;433(7027):760-4.
[11] Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282(5391):1145-7.
[12] Cruse JM, Lewis RE, Wang H. Immunology guidebook. New York: Acad, press, 2004. 502 p.
[13] Pavl?cek A, Clay O, Jabbari K, Paces J, Bernardi G. Isochore conservation between MHC regions on human chromosome 6 and mouse chromosome 17. FEBS Lett. 2002;511(1-3):175-7.
[14] Kordyum VA. Our "Shagreen leather" is our problem. And we have to solve it. 2. The united space of organism. Biopolym Cell. 2003; 19(4):328-49.
[15] Amit M, Carpenter MK, Inokuma MS, Chiu CP, Harris CP, Waknitz MA, Itskovitz-Eldor J, Thomson JA. Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture. Dev Biol. 2000;227(2):271-8.
[16] Draper JS, Smith K, Gokhale P, Moore HD, Maltby E, Johnson J, Meisner L, Zwaka TP, Thomson JA, Andrews PW. Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells. Nat Biotechnol. 2004;22(1):53-4.
[17] Maitra A, Arking DE, Shivapurkar N, Ikeda M, Stastny V, Kassauei K, Sui G, Cutler DJ, Liu Y, Brimble SN, Noaksson K, Hyllner J, Schulz TC, Zeng X, Freed WJ, Crook J, Abraham S, Colman A, Sartipy P, Matsui S, Carpenter M, Gazdar AF, Rao M, Chakravarti A. Genomic alterations in cultured human embryonic stem cells. Nat Genet. 2005;37(10):1099-103.
[18] McRae C, Cherin E, Diem G, Vo AH, Ellgring JH, Russell D, Fahn S, Freed C. Does personality change as a result of fetal tissue transplantation in the brain? J Neurol. 2003;250(3):282-6.
[19] Davydovskiy IV, Sarkisov RS. Cellular pathology. Great med encyclopedia. M.: Soviet Encyclopedia, 1986; vol 27:445-58.
[20] Kordyum VA. Evolution and the Biosphere. Kiev, Naukova Dumka, 1982. 282 p.
[21] Kordyum VA. About a conception of viruses and their place in the biosphere. Biopolym Cell. 2000; 16(2):87-98.
[22] Terada N, Hamazaki T, Oka M, Hoki M, Mastalerz DM, Nakano Y, Meyer EM, Morel L, Petersen BE, Scott EW. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature. 2002;416(6880):542-5.
[23] Ying QL, Nichols J, Evans EP, Smith AG. Changing potency by spontaneous fusion. Nature. 2002;416(6880):545-8.
[24] Vassilopoulos G, Wang PR, Russell DW. Transplanted bone marrow regenerates liver by cell fusion. Nature. 2003;422(6934):901-4.
[25] Kordyum VA. Our "Shagreen leather" is our problem. And we have to solve it. 3. A missing link. Biopolym Cell. 2003; 19(6):473-91.
[26] Chen XQ, Stroun M, Magnenat JL, Nicod LP, Kurt AM, Lyautey J, Lederrey C, Anker P. Microsatellite alterations in plasma DNA of small cell lung cancer patients. Nat Med. 1996;2(9):1033-5.
[27] Nawroz H, Koch W, Anker P, Stroun M, Sidransky D. Microsatellite alterations in serum DNA of head and neck cancer patients. Nat Med. 1996;2(9):1035-7. Actions
[28] Kordium VA, Shpilevaya SP, Ruban TA, Sukhorada OM, Andriyenko VI. Autotransformation of mammalian cells. Biopolym Cell. 2005; 21(2):140-4.
[29] Kordyum VA, Shpilevaya SP, Ruban TO, Sukhorada OM. The concept of genetic material exchange between mammalian cells. Biopolym Cell. 2005; 21(4):335-45.
[30] Kordyum VA, Shpylova SP, Andrienko VI, Sukhorada OM, Ruban TA, Deryabina OG. Transfer of genetic information in an organism. Cell Biol Int. 2005;29(1):95-7.
[31] AS N 9202 from 15.01.2004. A new phenomenon - the restoration and proof that it holds special cells. VA Kordyum, OM Sukhorada, TA Ruban, SP Shpilova. Publ.