Biopolym. Cell. 2006; 22(1):29-32.
Structure and Function of Biopolymers
Eukaryotic elongation factor 1A disintegrates aggregates of phenylalanyl-tRNA synthetase
- Institute of Molecular Biology and Genetics, NAS of Ukraine
150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
Translation elongation factor 1A (eEF1A) provides binding and transporting of the appropriate codon-specified aminoacyl-tRNA to the aminoacyl site of the ribosome. Two active tissue-specific isoforms of eEF1A have been identified in mammals. Herewith we report that two isoforms of eEF1A disintegrate the aggregates of phenylalanyl-tRNA synthetase like molecular chaperones which are involved in protein folding and renaturation after stress.
Keywords: translation elongation factor 1A, phenylalanyl-tRNA synthetase, chaperone, aggregation, thermodenaturation
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