Biopolym. Cell. 2005; 21(5):454-457.
Short Communications
Virus-induced breach of chromosome apparatus
1Yevtushenko A. I., 1Shirobokov V. P., 1Pavlenko L. V.
  1. Bogomolets National Medical University
    Blvd. Shevchenko, 13, Kyiv, Ukraine, 01601


The article is devoted to the investigation of the influence of intrauterine experimental enterovirus infection on the fetus chromosome apparatus. The analysis of a spectrum of cytogenetical breach in embryonic cells of mice (polyploidy, aneuploidy, the gaps in chromosomes) testifies, that these abnormalities depend on the species, type of viruses, the period of pregnancy.
Keywords: enteroviruses, intrauterine infection, chromosome apparatus


[1] Piersantelli N, Guida B, Robert L. [Problems of the prenatal prophylaxis of the viral infections (author's transl)]. Ann Sclavo. 1976;18(3):393-446.
[2] Arechavaleta-Velasco F, Koi H, Strauss JF 3rd, Parry S. Viral infection of the trophoblast: time to take a serious look at its role in abnormal implantation and placentation? J Reprod Immunol. 2002;55(1-2):113-21.
[3] Strong BS, Young SA. Intrauterine coxsackie virus, group B type 1, infection: viral cultivation from amniotic fluid in the third trimester. Am J Perinatol. 1995;12(2):78-9.
[4] Enders G. [Perinatal infections]. Ric Clin Lab. 1988;18 Suppl 1:109-16.
[5] Ventura KC, Hawkins H, Smith MB, Walker DH. Fatal neonatal echovirus 6 infection: autopsy case report and review of the literature. Mod Pathol. 2001;14(2):85-90.
[6] Buzhievskaya TI. Virus-induced mutagenesis in mammalian cells. Kyiv, Naukova dumka, 1984; 136 p.
[7] Ilinskih NN, Bocharov EF, Ilinskih IN. Infectious mutagenesis. Novosibirsk: Nauka. 1984. 180 p.
[8] Byshovets TF. Sensitivity of chromosome apparatus of mother cells and embryo cells to the influenza virus effect in the experiment. Tsitol Genet. 1975; 9(1): 19-21.
[9] Lozovskaya LS, Soboleva VD, Khelenova EA. Vertical transmission of human enteroviruses and some chronic form of congenital Coxsackie virus infection. Enteroviruses. Theoretical and medical aspects: Materials All-Union. conf. (March, 1991). Kiev, 1991;66-7.
[10] SHirobokov VP, Girin VN, YAkimenko AI, Zemlyanskiy VV, Kornyushenko ON, Evtushenko AI. The use of bentonite to detect enteroviruses in humans and in the environment. Method recommendation. Kiev, 1986; 22 p.
[11] Shirobokov VP. [Use of a bentonite layer for enterovirus titration by the plaque method]. Vopr Virusol. 1973;18(5):611-5.
[12] Manual for the virologichal investigation of polio, WHO. Moscow, 1998; 114 p.
[13] Shirobokov VP. Differentiation of coxsackieviruses based on the character of adsorption bentonite. Acta Virol. 1968;12(2):185.
[14] Shirobokov VP. A comparative study of the biological properties of Coxsackie viruses and their variants were selected: Author. dis. ... Dr. med. Sciences. Kiev, 1977; 36 p.
[15] Kurinny AI. A new method for preparation of the mammalian embryo chromosomes. Tsitol Genet. 1969; 3(5):453-5.
[16] Lapaya SI, Chubenko AV, Babich LN. Statistical methods in biomedical research using the Excel. Experimental studies. Clinical trials. The analysis of the pharmaceutical market. K.: Morion, 2000; 319 p.
[17] Mintser OP, Ugarov BN, Vlasov VV. Methods of processing of medical information. K.: Vyshcha Shkola, 1991; 271 p.