Biopolym. Cell. 2005; 21(3):283-286.
http://dx.doi.org/10.7124/bc.0006F3
Molecular Biophysics
About molecular mechanisms of fiber muscle contraction at transition to new equilibrium state: analysis of experimental data using three-componential electrical stimulating signal
1Nozdrenko D. N., 1Bogutska K. I.
  1. Taras Shevchenko National University of Kyiv
    64, Volodymyrska Str., Kyiv, Ukraine, 01033

Abstract

Molecular mechanisms of muscular fiber contraction from native conditions of rest are found to be more complex in comparison with those from conditions of preliminary pressure. An application of three-component electrical stimulating signal has revealed non-linearity of dynamic processes during an appropriate phase before tetanus contraction. It is possible that the slipping of actin and myosin protofibrils occurs with the formation of strong bounds of myosin heads with actin, which starts at the contraction from the rest state. The revealed non-linear dynamic characteristics of muscle contraction proof the complexities in creation of its adequate microstructural model.
Keywords: muscle contraction, muscular fiber, force, length, electrical stimulation, actin, myosin
Full text: (PDF, in Russian)

References

[1] Kostyukov AI. Dynamics of efferent control of muscular contraction. Determination of transition processes: External load?? Muscle length. Neurophysiology. 1986;17(3):238–46.
[2] Kostyukov AI, Korchak OE. Length changes of the cat soleus muscle under frequency-modulated distributed stimulation of efferents in isotony. Neuroscience. 1998;82(3):943-55.
[3] Miroshnichenko MS, Nozdrenko DM, Zaloilo IA. The dinamics of the isolated muscle fiber contraction at high-frequency modulated stimulation. Physics of the Alive. 2002; 10(1):41-8.
[4] Miroshnichenko MS, Zaloilo IA, Nozdrenko DM, Prylutskiy YuI. The dinamics of the isolated muscle fiber contraction. Physics of the Alive. 2001;9(2):71-8.
[5] Zaloilo IA, Nozdrenko DM, Soroka VM, Miroshnichenko MS. The reduction in single fibers of skeletal muscle in terms of abovethreshold electrostimulation. Visn Kyiv Univ biol. 2002; 36-37:106-8.
[6] Huxley AF. Muscular contraction. J Physiol. 1974;243(1):1-43.
[7] Huxley HE. The double array of filaments in cross-striated muscle. J Biophys Biochem Cytol. 1957;3(5):631-48.
[8] Tal’nov AN, Serenko SG, Cherkasskii VL, Strafun SS. Coordination of the dynamic phases of EMG activity in human elbow flexors in the performance of targeted tracking movements. Neurophysiology. 1998;30(3):168–78.
[9] Tal'nov AN, Serenko SG, Strafun SS, Kostyukov AI. Analysis of the electromyographic activity of human elbow joint muscles during slow linear flexion movements in isotorque conditions. Neuroscience. 1999;90(3):1123-36.