Biopolym. Cell. 2005; 21(2):134-139.
Role of molecular mimicry in detection of HIV infection
- Gromashevsky L.V. Institute of Epidemiology and Infection Diseases, AMS of Ukraine
5, Amosova Str., Kyiv, Ukraine, 03038
This review deals with a role of molecular mimicry in detection of the infection caused by the human immunodeficiency virus (HIV). The molecular mimicry is determined as the presence of either similar or completely identical primary amino acid sequence in proteins of different origin. Some HIV protein sequences are shown to be identical with several host ones, so the organism synthesizes antibodies interacting with its own structures; such situation may be a cause of false-positive results of sera testing by serological assays.
Keywords: HIV, molecular mimicry, antibodies, diagnostics
Full text: (PDF, in Ukrainian)
 Bresler SE. Introduction to Molecular Biology. M; L.: Nauka, 1966. 514 p.
 Bertoletti A, Cham F, McAdam S, Rostron T, Rowland-Jones S, Sabally S, Corrah T, Ariyoshi K, Whittle H. Cytotoxic T cells from human immunodeficiency virus type 2-infected patients frequently cross-react with different human immunodeficiency virus type 1 clades. J Virol. 1998;72(3):2439-48.
 Nakagawa K, Harrison LC. The potential roles of endogenous retroviruses in autoimmunity. Immunol Rev. 1996;152:193-236.
 Gifford R, Tristem M. The evolution, distribution and diversity of endogenous retroviruses. Virus Genes. 2003;26(3):291-315.
 Sverdlov ED. [Essays on modern molecular genetic. Essay 8. Genomic diseases and new molecular genetics. Part 2. Cancer--a genomic disease. "Cancer genes" and signal transduction in the cell]. Mol Gen Mikrobiol Virusol. 1999;(2):3-22.
 Abelev GI. Foreword. Bacteria, viruses, cancer immunity. Ed. NN Blokhin. L.: Meditsina. 1971;3-34.
 Zilber LA. Fundamentals of Immunology. M, 1958. 251 p.
 Reymers NF. Popular Dictionary of Biology. M.: Nauka, 1991. 544 p.
 Selby C. Interference in immunoassay. Ann Clin Biochem. 1999;36 (Pt 6):704-21.
 Quality assurance in laboratory examination в„ў infected with human immunodeficiency virus: Seminar under the auspices of the European Office of the World Health Organization. Saint Petersburg, 1993.; 39 p.
 Roitt I, Brostoff J, Male D. Immunology. Mosby-Year Book; 5th edition 1998 416 p.
 Bisset LR. Molecular mimicry in the pathogenesis of AIDS: the HIV/MHC/mycoplasma triangle. Med Hypotheses. 1994;43(6):388-96.
 Kanki PJ, Barin F, M'Boup S, Allan JS, Romet-Lemonne JL, Marlink R, McLane MF, Lee TH, Arbeille B, Denis F, et al. New human T-lymphotropic retrovirus related to simian T-lymphotropic virus type III (STLV-IIIAGM). Science. 1986;232(4747):238-43.
 Brun-Vezinet F, Rey MA, Katlama C, Girard PM, Roulot D, Yeni P, Lenoble L, Clavel F, Alizon M, Gadelle S, et al. Lymphadenopathy-associated virus type 2 in AIDS and AIDS-related complex. Clinical and virological features in four patients. Lancet. 1987;1(8525):128-32.
 Vladyko AS. Cross-immunoreactivity among the particularly dangerous philosopher Ebola, Marburg) and arena- (Lassa, Machupo) viruses. Sanitary protection of the territory of Ukraine and prevention of particularly dangerous infections: Proceedings of the conference on the 60th anniversary of the Ukrainian State Anti-Plague Station (30-31 Oct. 1997). Odessa, 1997;35-50.
 Srinivasappa J, Saegusa J, Prabhakar BS, Gentry MK, Buchmeier MJ, Wiktor TJ, Koprowski H, Oldstone MB, Notkins AL. Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues. J Virol. 1986;57(1):397-401. PubMed PMID: 2647867.
 Fujinami RS, Oldstone MB. Molecular mimicry as a mechanism for virus-induced autoimmunity. Immunol Res. 1989;8(1):3-15.
 Oldstone MB. Viruses and autoimmune diseases. Scand J Immunol. 1997;46(4):320-5.
 Trujillo JR, McLane MF, Lee TH, Essex M. Molecular mimicry between the human immunodeficiency virus type 1 gp120 V3 loop and human brain proteins. J Virol. 1993;67(12):7711-5.
 Price RW, Brew B, Sidtis J, Rosenblum M, Scheck AC, Cleary P. The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science. 1988;239(4840):586-92.
 Levy JA. HIV and the Pathogenesis of AIDS-Washington: ASM press, 1994. 359 p.
 Fitzgerald DJ, Bronson EC, Anderson JN. Compositional similarities between the human immunodeficiency virus and surface antigens of pathogens. AIDS Res Hum Retroviruses. 1996;12(2):99-106.
 Korber B, Brander C, Haynes B, Kaup R, Moore J, Walker B. Human retroviruses and AIDS. A compilation and analysis of nucleic acid and amino acid sequences. Los Alamos: National Laboratories press, 1999. 235 p.
 Doran TI, Parra E. False-positive and indeterminate human immunodeficiency virus test results in pregnant women. Arch Fam Med. 2000;9(9):924-9.