Biopolym. Cell. 2004; 20(6):535-542.
Bioorganic Chemistry
Research on sensitivity of biomodels for initial testing potential physiologically active substances by the method of cluster analysis
1Semeniuta I. V., 1Metelitsa L. A., 1Kalashnikova L. E., 1Prokopenko R. A.
  1. Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine
    1, Murmans'ka Str., Kyiv, Ukraine, 02094


The sensitivity of blood cells and functional activity of unstriped muscles to physiologically active substances of various chemical nature has been investigated. It is shown, that the stimulating of the chemotaxis and electrophoresis of leucocytes can be used for a tentative estimation of biological potency of new chemical materials, as well as for the further study of mechanisms of influence of various physiologically active substances on immunocompetent cells. The means of handling of heterogeneous and statistically uncertain data by the method of cluster analysis is offered.


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