Biopolym. Cell. 2004; 20(3):255-258.
Short Communications
Genetic determination of dissociation process of poliovirus type III
1Kostenko I. G., 1Zhuravel E. V., 1Panasenko G. V., 1Shirobokov V. P.
  1. Bogomolets National Medical University
    Blvd. Shevchenko, 13, Kyiv, Ukraine, 01601

Abstract

The variants of a vaccine virus strain of a poliomyelitis type III have been proved to occur in the course of reproduction in cell culture, and have differences in nucleotide sequences of a gene VP1. It has been demonstrated, that in variant Abent+ the nucleotide adenine occupies position 2900, and in variant Abent- - guanine. Accordingly, in the structure of protein VP1 an aspartic acid replaces asparagines in position 142, the former influencing the charge and conformation of virion surface proteins.

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