Biopolym. Cell. 1986; 2(2):59-68.
Reviews
Interaction between cellular and retroviral genomes in ontogenesis of mice
- Institute of Molecular Biology and Genetics, Academy of Sciences of the Ukrainian SSR
Kiev, USSR
Abstract
Certain data concerning retrovirus genome introduction into murine genome as well as retrovirus activation in different tissues depending on the virus localization in chromosome and ontogenesis period of mice are discussed.
Full text: (PDF, in Russian)
References
[1]
Wagner TE, Hoppe PC, Jollick JD, Scholl DR, Hodinka RL, Gault JB. Microinjection of a rabbit beta-globin gene into zygotes and its subsequent expression in adult mice and their offspring. Proc Natl Acad Sci U S A. 1981;78(10):6376-80.
[2]
Steward TA, Wagner EF, Mintz B. Human beta-globin gene sequences injected into mouse eggs, retained in adults, and transmitted to progeny. Science. 1982;217(4564):1046-8.
[3]
Anderson WF, Killos L, Sanders-Haigh L, Kretschmer PJ, Diacumakos EG. Replication and expression of thymidine kinase and human globin genes microinjected into mouse fibroblasts. Proc Natl Acad Sci U S A. 1980;77(9):5399-403.
[4]
Brinster RL, Chen HY, Warren R, Sarthy A, Palmiter RD. Regulation of metallothionein--thymidine kinase fusion plasmids injected into mouse eggs. Nature. 1982;296(5852):39-42.
[5]
Doehmer J, Barinaga M, Vale W, Rosenfeld MG, Verma IM, Evans RM. Introduction of rat growth hormone gene into mouse fibroblasts via a retroviral DNA vector: expression and regulation. Proc Natl Acad Sci U S A. 1982;79(7):2268-72.
[6]
Palmiter RD, Brinster RL, Hammer RE, Trumbauer ME, Rosenfeld MG, Birnberg NC, Evans RM. Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature. 1982;300(5893):611-5.
[7]
Grosschedl R, Weaver D, Baltimore D, Costantini F. Introduction of a mu immunoglobulin gene into the mouse germ line: specific expression in lymphoid cells and synthesis of functional antibody. Cell. 1984;38(3):647-58.
[8]
Brinster RL, Ritchie KA, Hammer RE, O'Brien RL, Arp B, Storb U. Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice. Nature. 1983 Nov 24-30;306(5941):332-6.
[9]
McKnight GS, Hammer RE, Kuenzel EA, Brinster RL. Expression of the chicken transferrin gene in transgenic mice. Cell. 1983;34(2):335-41.
[10]
Swift GH, Hammer RE, MacDonald RJ, Brinster RL. Tissue-specific expression of the rat pancreatic elastase I gene in transgenic mice. Cell. 1984;38(3):639-46.
[11]
Gazaryan KG, Gening LV, Neznanov NS, Andreeva LE, Makarova IV, Kuznetsova ED, Kosikov AI, Baranov YuN, Kucheryavyi VV, Alexeeva MV, Tarantul VZ. Microinjection of recombinant DNAs containing the thymidine kinase gene of the herpes virus and the retroviruse sequences into mice zygotes. Mol Gen Mikrobiol Virusol. 1984; 10:22-8.
[12]
Wei CM, Gibson M, Spear PG, Scolnick EM. Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type 1. J Virol. 1981;39(3):935-44.
[13]
Weiss RA. Retroviruses as host Mendelian elements. Folia Biol (Praha). 1983;29(2):156-63.
[14]
Van Beveren C, Goddard JG, Berns A, Verma IM. Structure of Moloney murine leukemia viral DNA: nucleotide sequence of the 5' long terminal repeat and adjacent cellular sequences. Proc Natl Acad Sci U S A. 1980;77(6):3307-11.
[15]
Shimotohno K, Mizutani S, Temin HM. Sequence of retrovirus provirus resembles that of bacterial transposable elements. Nature. 1980;285(5766):550-4.
[16]
Payne GS, Courtneidge SA, Crittenden LB, Fadly AM, Bishop JM, Varmus HE. Analysis of avian leukosis virus DNA and RNA in bursal tumours: viral gene expression is not required for maintenance of the tumor state. Cell. 1981;23(2):311-22.
[17]
Quintrell N, Hughes SH, Varmus HE, Bishop JM. Structure of viral DNA and RNA in mammalian cells infected with avian sarcoma virus. J Mol Biol. 1980;143(4):363-93.
[18]
Varmus HE, Quintrell N, Ortiz S. Retroviruses as mutagens: insertion and excision of a nontransforming provirus alter expression of a resident transforming provirus. Cell. 1981;25(1):23-36.
[19]
Jaenisch R. Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus. Proc Natl Acad Sci U S A. 1976;73(4):1260-4.
[20]
Breindl M, Doehmer J, Willecke K, Dausman J, Jaenisch R. Germ line integration of Moloney leukemia virus: identification of the chromosomal integration site. Proc Natl Acad Sci U S A. 1979;76(4):1938-42.
[21]
Jahner D, Jaenisch R. Integration of Moloney leukaemia virus into the germ line of mice: correlation between site of integration and virus activation. Nature. 1980;287(5781):456-8.
[22]
Jaenisch R, Jähner D, Nobis P, Simon I, Löhler J, Harbers K, Grotkopp D. Chromosomal position and activation of retroviral genomes inserted into the germ line of mice. Cell. 1981;24(2):519-29.
[23]
Harbers K, Schnieke A, Stuhlmann H, Jaenisch R. Infectivity and structure of molecular clones obtained from two genetically transmitted Moloney leukemia proviral genomes. Nucleic Acids Res. 1982;10(8):2521-37.
[24]
Chumakov I, Stuhlmann H, Harbers K, Jaenisch R. Cloning of two genetically transmitted Moloney leukemia proviral genomes: correlation between biological activity of the cloned DNA and viral genome activation in the animal. J Virol. 1982;42(3):1088-98.
[25]
Jaenisch R. Retroviruses and embryogenesis: microinjection of Moloney leukemia virus into midgestation mouse embryos. Cell. 1980;19(1):181-8.
[26]
Stewart C, Harbers K, Jähner D, Jaenisch R. X chromosome-linked transmission and expression of retroviral genomes microinjected into mouse zygotes. Science. 1983;221(4612):760-2.
[27]
Verma IM. Genome organization of RNA tumor viruses. I. In vitro synthesis of full-genome-length single-stranded and double-stranded viral DNA transcripts. J Virol. 1978;26(3):615-29.
[28]
Gilboa E, Goff S, Shields A, Yoshimura F, Mitra S, Baltimore D. In vitro synthesis of a 9 kbp terminally redundant DNA carrying the infectivity of Moloney murine leukemia virus. Cell. 1979;16(4):863-74.
[29]
Groner B, Buetti E, Diggelmann H, Hynes NE. Characterization of endogenous and exogenous mouse mammary tumor virus proviral DNA with site-specific molecular clones. J Virol. 1980;36(3):734-45.
[30]
van der Putten H, Terwindt E, Berns A, Jaenisch R. The integration sites of endogenous and exogenous Moloney murine leukemia virus. Cell. 1979;18(1):109-16.
[31]
Bacheler LT, Fan H. Multiple integration sites for Moloney murine leukemia virus in productively infected mouse fibroblasts. J Virol. 1979;30(3):657-67.
[32]
Rein AL, Gerwin BI, Bassin RH, Schwarm L, Schidlovsky G. A replication-defective variant of Moloney murine leukemia virus. I. Biological characterization. J Virol. 1978;25(1):146-56.
[33]
Shields A, Witte WN, Rothenberg E, Baltimore D. High frequency of aberrant expression of Moloney murine leukemia virus in clonal infections. Cell. 1978;14(3):601-9.
[34]
Schnieke A, Stuhlmann H, Harbers K, Chumakov I, Jaenisch R. Endogenous Moloney leukemia virus in nonviremic Mov substrains of mice carries defects in the proviral genome. J Virol. 1983;45(2):505-13.
[35]
Harbers K, Schnieke A, Stuhlmann H, Jähner D, Jaenisch R. DNA methylation and gene expression: endogenous retroviral genome becomes infectious after molecular cloning. Proc Natl Acad Sci U S A. 1981;78(12):7609-13.
[36]
Stuhlmann H, Jahner D, Jaenisch R. Infectivity and methylation of retroviral genomes is correlated with expression in the animal. Cell. 1981;26(2 Pt 2):221-32.
[37]
Vardimon L, Neumann R, Kuhlmann I, Sutter D, Doerfler W. DNA methylation and viral gene expression in adenovirus-transformed and -infected cells. Nucleic Acids Res. 1980;8(11):2461-73.
[38]
Groudine M, Eisenman R, Weintraub H. Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation. Nature. 1981;292(5821):311-7.
[39]
Cohen JC. Methylation of milk-borne and genetically transmitted mouse mammary tumor virus proviral DNA. Cell. 1980;19(3):653-62.
[40]
Doerfler W. DNA methylation--a regulatory signal in eukaryotic gene expression. J Gen Virol. 1981;57(Pt 1):1-20.
[42]
Razin A, Webb C, Szyf M, Yisraeli J, Rosenthal A, Naveh-Many T, Sciaky-Gallili N, Cedar H. Variations in DNA methylation during mouse cell differentiation in vivo and in vitro. Proc Natl Acad Sci U S A. 1984;81(8):2275-9.
[43]
Naveh-Many T, Cedar H. Active gene sequences are undermethylated. Proc Natl Acad Sci U S A. 1981;78(7):4246-50.
[44]
Jaenisch R, Schnieke A, Harbers K. Treatment of mice with 5-azacytidine efficiently activates silent retroviral genomes in different tissues. Proc Natl Acad Sci U S A. 1985;82(5):1451-5.
[45]
Jahner D, Stuhlmann H, Stewart CL, Harbers K, Lohler J, Simon I, Jaenisch R. De novo methylation and expression of retroviral genomes during mouse embryogenesis. Nature. 1982;298(5875):623-8.
[46]
Palmiter RD, Chen HY, Brinster RL. Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring. Cell. 1982;29(2):701-10.
[47]
Stewart CL, Stuhlmann H, Jahner D, Jaenisch R. De novo methylation, expression, and infectivity of retroviral genomes introduced into embryonal carcinoma cells. Proc Natl Acad Sci U S A. 1982;79(13):4098-102.
[48]
Razin A, Szyf M. DNA methylation patterns. Formation and function. Biochim Biophys Acta. 1984;782(4):331-42.
[49]
Yaniv M. Regulation of eukaryotic gene expression by transactivating proteins and cis acting DNA elements. Biol Cell. 1984;50(3):203-16.
[50]
McKeon C, Ohkubo H, Pastan I, de Crombrugghe B. Unusual methylation pattern of the alpha 2 (l) collagen gene. Cell. 1982;29(1):203-10.
[51]
Mather EL, Perry RP. Methylation status and DNase I sensitivity of immunoglobulin genes: changes associated with rearrangement. Proc Natl Acad Sci U S A. 1983;80(15):4689-93.
[52]
Jahner D, Stuhlmann H, Jaenisch R. Conformation of free and of integrated Moloney leukemia virus proviral DNA in preleukemic and leukemic BALB/Mo mice. Virology. 1980;101(1):111-23.
[53]
Jaenisch R. Moloney leukemia virus gene expression and gene amplification in preleukemic and leukemic BALB/Mo mice. Virology. 1979;93(1):80-90.
[54]
Chapman AB, Costello MA, Lee F, Ringold GM. Amplification and hormone-regulated expression of a mouse mammary tumor virus-Eco gpt fusion plasmid in mouse 3T6 cells. Mol Cell Biol. 1983;3(8):1421-9.
[55]
Nobis P, Jaenisch R. Passive immunotherapy prevents expression of endogenous Moloney virus and amplification of proviral DNA in BALB/Mo mice. Proc Natl Acad Sci U S A. 1980;77(6):3677-81.
[56]
Harbers K, Jahner D, Jaenisch R. Microinjection of cloned retroviral genomes into mouse zygotes: integration and expression in the animal. Nature. 1981 Oct 15-21;293(5833):540-2.
[57]
Fiedler W, Nobis P, Jahner D, Jaenisch R. Differentiation and virus expression in BALB/Mo mice: endogenous Moloney leukemia virus is not activated in hematopoietic cells. Proc Natl Acad Sci U S A. 1982;79(6):1874-8.
[58]
Hayashi S., Kondoh H., Okada T. S. delta-crystallin gene expression: the requirement of upstream region. Develop Growth Differ. 1984. 26(4):961.
[59]
Okada TS, Kondoh H, Hayashi S, Yasuda K. Tissue-specific expression of delta-crystallin gene as demonstrated by the intranuclear injection of cloned genes. J Embriol Exp Morphol. 1984;82(Suppl):138.
[60]
Breindl M, Bacheler L, Fan H, Jaenisch R. Chromatin conformation of integrated Moloney leukemia virus DNA sequences in tissues of BALB/Mo mice and in virus-infected cell lines. J Virol. 1980;34(2):373-82.
[61]
van der Putten H, Quint W, Verma IM, Berns A. Moloney murine leukemia virus-induced tumors: recombinant proviruses in active chromatin regions. Nucleic Acids Res. 1982;10(2):577-92.
[62]
Breindl M, Nath U, Jahner D, Jaenisch R. DNase I sensitivity of endogenous and exogenous proviral genome copies in M-MuLV-induced tumors of Mov-3 Mice. Virology. 1982;119(1):204-8.
[63]
Schnieke A, Harbers K, Jaenisch R. Embryonic lethal mutation in mice induced by retrovirus insertion into the alpha 1(I) collagen gene. Nature. 1983 Jul 28-Aug 3;304(5924):315-20.
[64]
Jaenisch R, Harbers K, Schnieke A, Lohler J, Chumakov I, Jähner D, Grotkopp D, Hoffmann E. Germline integration of moloney murine leukemia virus at the Mov13 locus leads to recessive lethal mutation and early embryonic death. Cell. 1983;32(1):209-16.
[65]
Harbers K, Kuehn M, Delius H, Jaenisch R. Insertion of retrovirus into the first intron of alpha 1(I) collagen gene to embryonic lethal mutation in mice. Proc Natl Acad Sci U S A. 1984;81(5):1504-8.
[66]
Breindl M, Harbers K, Jaenisch R. Retrovirus-induced lethal mutation in collagen I gene of mice is associated with an altered chromatin structure. Cell. 1984;38(1):9-16.
[67]
Wasylyk B, Chambon P. Potentiator effect of the SV40 72-bp repeat on initiation of transcription from heterologous promoter elements. Cold Spring Harb Symp Quant Biol. 1983;47 Pt 2:921-34.
[68]
Wagner EF, Covarrubias L, Stewart TA, Mintz B. Prenatal lethalities in mice homozygous for human growth hormone gene sequences integrated in the germ line. Cell. 1983;35(3 Pt 2):647-55.
[69]
Copeland NG, Hutchison KW, Jenkins NA. Excision of the DBA ecotropic provirus in dilute coat-color revertants of mice occurs by homologous recombination involving the viral LTRs. Cell. 1983;33(2):379-87.
[70]
Copeland NG, Jenkins NA, Lee BK. Association of the lethal yellow (Ay) coat color mutation with an ecotropic murine leukemia virus genome. Proc Natl Acad Sci U S A. 1983;80(1):247-9.
[71]
Stuhlmann H, Cone R, Mulligan RC, Jaenisch R. Introduction of a selectable gene into different animal tissue by a retrovirus recombinant vector. Proc Natl Acad Sci U S A. 1984;81(22):7151-5.