Biopolym. Cell. 2003; 19(5):467-471.
Bioorganic Chemistry
Antitumor activity of 6-substituted derivatives of 4-alkylaminoquinazolines
1Sapelkin V. M., 1Makovenko I. E., 1Lukashov S. S., 1Dubinina G. G., 1Yarmoluk S. M.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680


13 derivatives of 6-R-4-alkylaminoauinazoline were synthesized and tested for antitumor activity (in vitro). According to the resultes of testing with 56 human tumor cell lines four compounds 4.1, 4.9–4.11 were shown to inhibit the proliferation of cancer cells at low micromotor concentrations, 1-phenylethylf 4 quinuzolinylfamine (4.1) exhibits antitumor activity: GI50– 2.29 μ; LC50 –46.7mkM (cell line SK-MFL-5 (Melanoma)); the 6-bromo4 auinazolinyKtert-butyDamine (4. to): GI50 3 82 μM; LC50 –43.7 μM (cell line SK-MEl.-S (Melanoma)) and GI50 –2.64 μM, LC50– 44.2 μM (cell line CAKI-l (Renal Cancer)).


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