Biopolym. Cell. 2003; 19(3):287-291.
Bioorganic Chemistry
Search for antitumor activity among derivatives of the 2,5-dihydropyrrole-2,5-dione
1Tarnavskiy S. S., 1Dubinina G. G., 1Golovach S. M., 1Yarmoluk S. M.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680


39 derivatives of the 2,5-dihydropyrrole-2,5-dione were synthesized and tested on antitumor activity. The l-benzyl-3-chloro-4-(3-hydro-xyanilino)-2,5-dihydro-IH-2,5-pyrroledione (5.2) was selected after pre-screening and tested on 56 cell lines of human tumors. The compound 5.2 exhibits antitumor activity: CI50 2.68μM, LC50 31.7 μM (cell line MDA-MB-435 (Breast Cancer)); GI50 3.35 μM, LC50 37.6 μM (cell line OVCAR-3 (Ovarian Cancer)); GI50 6.75 μM, LC50 44.5 μM (cell line NCI-H23 (Non-small Cell Lung Cancer)).


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