Biopolym. Cell. 2003; 19(3):287-291.
Search for antitumor activity among derivatives of the 2,5-dihydropyrrole-2,5-dione
- Institute of Molecular Biology and Genetics, NAS of Ukraine
150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
39 derivatives of the 2,5-dihydropyrrole-2,5-dione were synthesized and tested on antitumor activity. The l-benzyl-3-chloro-4-(3-hydro-xyanilino)-2,5-dihydro-IH-2,5-pyrroledione (5.2) was selected after pre-screening and tested on 56 cell lines of human tumors. The compound 5.2 exhibits antitumor activity: CI50 2.68μM, LC50 31.7 μM (cell line MDA-MB-435 (Breast Cancer)); GI50 3.35 μM, LC50 37.6 μM (cell line OVCAR-3 (Ovarian Cancer)); GI50 6.75 μM, LC50 44.5 μM (cell line NCI-H23 (Non-small Cell Lung Cancer)).
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