Biopolym. Cell. 2003; 19(3):270-273.
Viruses and Cell
New endogenous retrovirus from the chicken genome
1Borisenko L. G., 1Rynditch A. V.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680


Pro and pol genes of a novel HERV-1-related retrovirus have been sequenced from the chicken genome. This is the first discovery of not-ALV-related endogenous retrovirus in the genome of domestic chicken. This retrovirus is similar to the MLV-related retroviruses which are widespread within genomes of vertebrates. Nevertheless, the novel retrovirus is not clustered with the MLV-related exogenous spleen necrosis virus (SNV) infecting chicken. The chicken HERV-I-related retrovirus is shown to be expressed in embryo fibroblasts.


[1] Herniou E, Martin J, Miller K, Cook J, Wilkinson M, Tristem M. Retroviral diversity and distribution in vertebrates. J Virol. 1998;72(7):5955-66.
[2] Geryk J, Dez?l?e P, Barnier JV, Svoboda J, Nehyba J, Karakoz I, Rynditch AV, Yatsula BA, Calothy G. Transduction of the cellular src gene and 3' adjacent sequences in avian sarcoma virus PR2257. J Virol. 1989;63(2):481-92.
[3] Yatsula BA, Geryk J, Briestanska J, Karakoz I, Svoboda J, Rynditch AV, Calothy G, Dez?l?e P. Origin and evolution of the c-src-transducing avian sarcoma virus PR2257. J Gen Virol. 1994;75 ( Pt 10):2777-81.
[4] Venugopal K. Avian leukosis virus subgroup J: a rapidly evolving group of oncogenic retroviruses. Res Vet Sci. 1999;67(2):113-9.
[5] Robinson HL, Astrin SM, Senior AM, Salazar FH. Host Susceptibility to endogenous viruses: defective, glycoprotein-expressing proviruses interfere with infections. J Virol. 1981;40(3):745-51.
[6] Crittenden LB, Fadly AM, Smith EJ. Effect of endogenous leukosis virus genes on response to infection with avian leukosis and reticuloendotheliosis viruses. Avian Dis. 1982;26(2):279-94.
[7] Kuhnlein U, Fairfull RW, Gowe R, Kulenkamp A, Mou L, Zadworny D. Synergism between the endogenous viral loci ev6 and ev9 in inducing immunological tolerance to avian leukosis virus. Br Poult Sci. 1993;34(1):93-104.
[8] Borisenko LG, Rynditch AV. Avian endogenous retroviruses: structure, expression and evolution. Biopolym Cell. 2002; 18(1):37-47.
[9] Dimcheff DE, Drovetski SV, Krishnan M, Mindell DP. Cospeciation and horizontal transmission of avian sarcoma and leukosis virus gag genes in galliform birds. J Virol. 2000;74(9):3984-95.
[10] Martin J, Herniou E, Cook J, O'Neill RW, Tristem M. Interclass transmission and phyletic host tracking in murine leukemia virus-related retroviruses. J Virol. 1999;73(3):2442-9.
[11] Martin J, Herniou E, Cook J, Waugh O'Neill R, Tristem M. Human endogenous retrovirus type I-related viruses have an apparently widespread distribution within vertebrates. J Virol. 1997;71(1):437-43.
[12] Tristem M. Amplification of divergent retroelements by PCR. Biotechniques. 1996;20(4):608-12.
[13] Felsenstein J. PHYLIP-Phylogeny Inference Package (version 3.2). Cladistics. 1989;(5):164-6.
[14] Maniatis T, Fritsch EF, Sambrook J. Molecular cloning: a laboratory manual. New York: Cold Spring Harbor Lab. publ., 1982. 545 p.
[15] Xiong Y, Eickbush TH. Origin and evolution of retroelements based upon their reverse transcriptase sequences. EMBO J. 1990;9(10):3353-62.
[16] Haas NB, Grabowski JM, North J, Moran JV, Kazazian HH, Burch JB. Subfamilies of CR1 non-LTR retrotransposons have different 5'UTR sequences but are otherwise conserved. Gene. 2001;265(1-2):175-83.
[17] Chen PY, Cui Z, Lee LF, Witter RL. Serologic differences among nondefective reticuloendotheliosis viruses. Arch Virol. 1987;93(3-4):233-45.
[18] Coffin J. Endogenous viruses. RNA tumor viruses. New York, 1984: 1109-1203.