Biopolym. Cell. 2003; 19(2):196-201.
Bioorganic Chemistry
Inhibitors of cyclin-dependent kinases. Synthesis of combinatorial libraries of 3-phenoxy-7-hydroxy-8-alkylaminomethylchromone derivatives and study on their anticancer activity
1Arkhipov V. V., 1Prikhod'ko A. O., 1Golub A. G., 2Khilya V. P., 1Yarmoluk S. M.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. Taras Shevchenko National University of Kyiv
    64, Volodymyrska Str., Kyiv, Ukraine, 01033


Cyclin-dependent kinases (CDK) play an important role in the cell cycle regulation. CDK are used as targets in a search for anticancer drugs. This study was aimed at the synthesis of 3-aryloxy-7-hydroxy-8-alkylaminomethylchromone derivatives, potential inhibitors of CDK. The antitumor activity of the compounds synthesyzed has been tested using 60 human tumor cell lines. 4 of the compounds tested have been revealed to inhibit the tumor cells proliferation.


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