Biopolym. Cell. 2003; 19(2):133-139.
http://dx.doi.org/10.7124/bc.000645
Structure and Function of Biopolymers
Dependence of the receptor-lectin interaction on radiation mode and dose in Chornobyl accident liquidators
1Karpova I. S., 1Koretskaya N. V.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

Lectins from 24 species of medicinal plants have been used in the investigation of blood red cell membranes of liquidators exposed to low and high doses of continual radiation and persons suffered from acute radiation sickness (ARS) due to Chornobyl accident Significant difference in the intensity of receptor-lectin interactions (integral IN index) between all groups of exposed and control persons has been demonstrated, that correlates with some qualitative and quantitative parameters of ionizing radiation. In each group under study there were also found peculiarities of the reactions with individual lectins, thus evidencing structural and functional changes in the cellular receptors. This reflects some deviations in the physiological status of organism in the late period after the accident.
Full text: (PDF, in Russian)

References

[1] Lutsik MD. Lectins. Chemical encyclopedia. M: Sov. entsiklopediya, 1990. Vol. 2:585-6.
[2] Lutsik AD, Detyuk AS, Lutsik MD. Lectin in histochemistry. Lviv: Lviv Univ. publ., 1989 144 p.
[3] Gabius HJ. Animal lectins. Eur J Biochem. 1997;243(3):543-76. Review.
[4] Gabius S, Kayser K, Bovin NV, Yamazaki N, Kojima N, Kaltner H, Gabius H-J. Endogenous lectins and neoglycoconjugates: a sweet approach to tumor diagnosis and targeted drug delivery. Eur J Pharm Biopharm. 1996. 42(2):250-61.
[5] Golynskaya EL, Pogorelaya NF, Makarenko VI. Lectins as possible pharmacologically active ingredient in some medicinal plants. The study and application of lectins. Lectins in biology and medicine. Uch. zapiski Tartus. un-ta. 1989;2(870):212-7.
[6] Osmak AA, Golynskaya EL, Makarenko VI, Sokirko PR. Lectins medicinal plants in immunodiagnostics and forecasting. The study and application of lectins. Lectins in biology and medicine. Uch zapiski Tartus. un-ta. 1989. 2(870):217-21.
[7] Gluzman DF, Bovin NV, Abramenko IV, Sklyarenko LM. Endogeneous lectins of cells of the immune system and lymphoid neoplasms. Eksp Onkol. 1992; 14(2):13-22.
[8] Lutsik MD, Panasjuk EN, Antonyuk VA, Lutsik AD, Ladnaya LYa. Method for investigation carbohydrate specificity of lectins (Methodical recommendation). Lviv, 1983 20 p.
[9] Karpova IS, Golynskaya EL, Koretskaya NV, Tikhonova TN, Pidpala OV, Mikhailovskaya EV. Diagnostical properties of lectines from medicinal herbs in investigation of person who received low irradiation doses in connection with Chernobyl accident. Dopovidi Akad Nauk Ukrainy. 1994;(1):110-3.
[10] Tepperman J, Tepperman HM. Metabolic and Endocrine Physiology. 5th ed. Year Book Medical Publishers Inc., Chicago, IL. 1987;
[11] Yablokov AV. Nuclear mythology. Notes ecologist about the nuclear industry. M.: Nauka, 1997; 272 p.
[12] Khalyavka IG. The health status of persons who have suffered acute radiation sickness during the Chernobyl disaster and measures for its improvement: Auth. Thesis. ... Dr med. nauk. Kuiv: «Geoinform», 1996; 43 p.
[13] Khalyavka IG, Kovalenko AN. The health status of employees Chernobyl involved in the accident in 1986 .. The Chernobyl Nuclear Power Plant - Slavutych: med. aspects. Eds VG Bebeshko, AV Nosovkiy, DA Bazyka. Kiev: Vyshcha shkola, 1996:249-54.
[14] Golynskaya EL, Karpova S, Koretskaya NY, Tykhonova TN, Mykhailovskaya EV, Khalyavka IG, Ovsjannikova LM. Investigation of interaction between lectins and peripheral blood red cells of patients which have been subjected to various doses of irradiation in connection with Chernobyl accident: 17th Int. Lectin Meeting (Wurzburg, Germany). Eur J Cell Biol. 1997;74(Suppl. 46):15.
[15] Karpova IS, Koretskaya NV, Khalyavka IG, Ovsyannikova LM. Haemagglutination test with a set of lectins from medicinal plants as an indicator of physiological status of the liquidators of the Chernobyl accident. Mezhdunar Zh Radiats meditsiny. 2001; 3(1):204-7
[16] Ovsyannikova LM, Alekhina SM, Progpas AF, Drobinskaya OV, Atamanenko ON. The health status of employees Chernobyl involved in the accident in 1986 .. The Chernobyl Nuclear Power Plant - Slavutych: med. aspects... Eds VG Bebeshko, AV Nosovkiy, DA Bazyka. Kiev: Vyshcha shkola, 1996;231-6.