Biopolym. Cell. 2003; 19(1):19-30.
http://dx.doi.org/10.7124/bc.000638
Reviews
Molecular mechanisms of astrocytic gliomas carcinogenesis
1Garifulin O. M., 1Dmitrenko V. V., 1Kavsan V. M.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

Basic genetic alterations which lead to forming the astocytic gliomas of grade II–IV are described in the review. The data concerning the genetic elements, participating in the malignant transformation of astocytic cells, are summarized. The molecular mechanisms of the arising de novo and developing of the secondary astrocytic tumors are analyzed. The molecular characteristics of carcinogenesis of different malignancy grades astrocytic gliomas are compared. The general and specific elements that determine the malignant progression of astrocytic gliomas are described.
Full text: (PDF, in Russian)

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