Biopolym. Cell. 2002; 18(5):394-400.
http://dx.doi.org/10.7124/bc.00061C
Structure and Function of Biopolymers
Possible molecular mechanisms of untargeted mutagenesis upon a post-replication SOS-reparation after irradiating two-stranded DNA by ultra-violet light
1Grebneva H. A.
  1. Donetsk Institute for Physics and Engineering named after O. O. Galkin, NAS of Ukraine
    72, R. Luxembourg Str., Donetsk, Ukraine, 83114

Abstract

Possible molecular mechanisms of an untargeted mutagenesis after post-replication SOS-reparation, resulting in formation of adjacent thymine dinners in both DNA chains are analyzed on the qualitative level It is suggested that a dimer is mutagenic only if one or two bases are in rare tautomeric forms and the control over tautomeric states of the template bases at DNA synthesis is diminished due to the SOS-induction. The potential mutations in this case are assumed to be the adenine residues in rare tautomeric forms located in the vicinity of dinners – exactly, opposite to the thymines forming other dimers with changes in their tautomeric state. They can result in transitions, transversions and frameshift mutations.
Full text: (PDF, in Russian)

References

[1] Grebneva HA. The nature and possible mechanisms of potential mutations formation due to the appearance of tymine dimers after irradiating two-stranded DNA by ultra-violet light. Biopolym Cell. 2002; 18(3):205-18.
[2] Grebneva HA. The molecular mechanisms derivation of mutation bases alteration after a postreplication SOS-reparation an DNA contaning thymine dimers. Biopolym Cell. 2001; 17(6):487-500.
[3] Hutchinson F. Chemical changes induced in DNA by ionizing radiation. Prog Nucleic Acid Res Mol Biol. 1985;32:115-54.
[4] Lawrence CW, Christensen RB. The mechanism of untargeted mutagenesis in UV-irradiated yeast. Mol Gen Genet. 1982;186(1):1-9.
[5] Lawrence CW, Le Clerc JE, Christensen JR, Christensen RB, Tata PV, Benerjee SK. Laci sequence changes and the mechanisms of UV mutagenesis in E coli. Radiat Res. 1987; 2: 538-43.
[6] Hagen U. Biochemical aspects of radiation biology. Experientia. 1989;45(1):7-12.
[7] Grebneva OA, Ivanov MO. The possible molecular mechanisms of untargeted type mutations formation under SOS-replication of two-stranded DNA. Biopolym Cell. 2001; 17(5):388-95.
[8] Lawrence CW, Banerjee SK, Borden A, LeClerc JE. T-T cyclobutane dimers are misinstructive, rather than non-instructive, mutagenic lesions. Mol Gen Genet. 1990;222(1):166-8.
[9] Poltev VI, Shuliupina NV, Bruskov VI. Molecular mechanisms of nucleic acid biosynthesis validity. Comparison of results of computer modeling with experimental data. Mol Biol (Mosk). 1998;32(2):268-76.
[10] Bresler SE. About solved and unsolved problems of mutagenesis and repair. Damage and DNA repair. Pushchino, 1980: 16-26.
[11] Watson JD, Crick FH. The structure of DNA. Cold Spring Harb Symp Quant Biol. 1953;18:123-31.
[12] Streisinger G, Okada Y, Emrich J, Newton J, Tsugita A, Terzaghi E, Inouye M. Frameshift mutations and the genetic code. This paper is dedicated to Professor Theodosius Dobzhansky on the occasion of his 66th birthday. Cold Spring Harb Symp Quant Biol. 1966;31:77-84.
[13] Strand M, Prolla TA, Liskay RM, Petes TD. Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature. 1993;365(6443):274-6.
[14] Clementi E, Corongiu G, Detrich J, Chin S, Domingo L. Parallelism in quantum chemistry: Hydrogen bond study in DNA base pairs as an example. Int J Quantum Chem. 1984;26(S18):601–18.
[15] Raghunathan G, Kieber-Emmons T, Rein R, Alderfer JL. Conformational features of DNA containing a cis-syn photodimer. J Biomol Struct Dyn. 1990;7(4):899-913.
[16] Krutiakov VM. Logical regulation of DNA polymerase mutagenesis and autonomous 3'-5'-exonuclease. Mol Biol (Mosk). 1998;32(2):229-32.
[17] Mikha?lov VS. DNA polymerases of eukaryotes. Mol Biol (Mosk). 1999;33(4):567-80.
[18] Chekhlov AN. Crystallographic evidence for intramolecular C?H...O interactions in principal nucleosides. Refinement of the crystal structure of thymidine. J Struct Chem. 1995;36(1):155–61.
[19] Volkenshtein MV, Golovanov IB, Sobolev VM. Molecular orbitals in enzymology. M.: Nauka, 1982; 239 p.
[20] Yang Y, Kunz BA. Naturally-occurring single nucleotide loops are corrected more efficiently than base mismatches in yeast. Envirion Mol Mutagenes. 1994. 23, Suppi.,23: 75.