Biopolym. Cell. 2002; 18(3):253-254.
Short Communications
Among Escherichia coli Genetic Stock Center strains many are resistant to cytotoxic antimetabolites
1Cherepenko E. I., 1Karpenko O. I.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680


Mutants resistant to cytotoxic antimetabolites arise in E. coli with a frequency about 10–4. Because most in this collection strains contacted a mutagen we checked how many strains could tolerate two inhibitors used: glyphosate and 6-aza-uracil. Among 28 strains studied 12 could tolerate these inhibitors.


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