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Among Escherichia coli Genetic Stock Center strains many are resistant to cytotoxic antimetabolites
- Institute of Molecular Biology and Genetics, NAS of Ukraine
150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
Mutants resistant to cytotoxic antimetabolites arise in E. coli with a frequency about 10–4. Because most in this collection strains contacted a mutagen we checked how many strains could tolerate two inhibitors used: glyphosate and 6-aza-uracil. Among 28 strains studied 12 could tolerate these inhibitors.
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