Biopolym. Cell. 2002; 18(2):161-163.
Antiviral properties of de novo designed proteins based on the albeferon and the fragment LKDRHDF (30–36) from human interferon-α2
1Chertkova R. V., 1Stepanenko N. A., 1Dolgikh D. A.
  1. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of bioorganic chemistry, RAS
    16/10, Miklukho-Maklaya Str., Moscow, Russian Federation, 117997


Two biologically active de novo proteins, ABB1-11 and ABBI-1, were engineered by including the fragment LKDRHDF (30–36) from human interferon-α2 (HuJFN-α2) into the N- and C-termini of albeferon – de novo protein with predesigned structure and function. It was shown that both proteins prevented the destruction of the L-41 and VERO cell monolayers generated by cytopathical action of a virus with the efficiency of native HuIFN-α2 and did not possess cytotoxicological properties.


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