Mass spectrometry (252Cf-PDMS) study of aminoglycoside antibiotics interaction with nucleic acid components

Kalinkevich, A. N.; Pilipenko, V. V.; Kalinichenko, T. G.; Sukhodub, L. F.

doi:10.7124/bc.0005F1

Biopolym. Cell. 2002; 18(2):114-116.

http://dx.doi.org/10.7124/bc.0005F1

Mass spectrometry (²⁵²Cf-PDMS) study of aminoglycoside antibiotics interaction with nucleic acid components

1Kalinkevich A. N., 1Pilipenko V. V., 1Kalinichenko T. G., 1Sukhodub L. F.

Institute of Applied Physics, NAS of Ukraine
58, Petropavlivska Str., Sumy, Ukraine, 40030

Abstract

Relative affinity of the aminoglycoside antibiotic streptomycine to nucleosides – adenosine, uridine, guanosine, cytidine was studied by the plasma desorption mass spectrometry ( Cf-PDMS). It has been shown that the affinity decreases in the row Urd > Ado > Cyd >Guo.

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References

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