Synthesis of novel 2\',3\'-dideoxy-6-azacytidine derivatives – potential retroviral reproduction inhibitors

Kostina, V. G.; Alexeeva, I. V.; Palchikovskaya, L. I.

doi:10.7124/bc.0005E1

Biopolym. Cell. 2001; 17(6):560-564.

http://dx.doi.org/10.7124/bc.0005E1

Bioorganic Chemistry

Synthesis of novel 2',3'-dideoxy-6-azacytidine derivatives – potential retroviral reproduction inhibitors

1Kostina V. G., 1Alexeeva I. V., 1Palchikovskaya L. I.

Institute of Molecular Biology and Genetics, NAS of Ukraine
150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

This paper deals with the synthesis of the novel 2',3'-dihalo-2',3'-dideoxy- and 2',3'-didehydro-2',3'-dideoxy-analogues of 6-azacytidine as potential antiviral substances. The compounds were prepared by means of the appropriate reagents – triphenylphosphonium halogen salts. The first step of the 6-azacytidine conversion results in 2,3-epoxynucleosides as against deoxygenation of uridine and thymidine, when O2, 2'-cyclonucleosides are generated.

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