Biopolym. Cell. 2001; 17(5):428-433.
Heparin and rat brain heparin-binding proteins take part in the process of hyperalgesia
- Dnipropetrovsk National University Oles Gonchar
72, Gagarin Av., Dnipropetrovs'k, Ukraine, 49050
It was shown that a hyperalgesia state resulted in the decrease of the mast cell degranulation degree and therefore diminished the amount of free heparin. In-parallel, the augmentation of heparin-binding activity of the rat brain proteins in hemispheres was detected. The morphine or ketamine application 5 min prior to operation preserves the heparin-binding activity of these proteins at the preoperative level
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