Biopolym. Cell. 2001; 17(4):325-330.
Bioorganic Chemistry
Preparative synthesis and some properties of deoxyribosylurea, the product of DNA oxidative degradation
1Dubey I. Y., 1Dubey L. V.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680


An efficient method for the preparation of 2'-deoxyribosylurea is proposed that includes the oxidation of 5'-O-protected thymidine with potassium permanganate and alkaline hydrolysis of intermediate thymidine glycol. The possibility of detection of urea residues in oligonucleotides has been studied.


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