Biopolym. Cell. 2001; 17(4):302-307.
http://dx.doi.org/10.7124/bc.0005BC
Genome and Its Regulation
Isolation, expression analysis and chromosomal mapping of a novel human kinase gene MLK4
1, 2Kvasha S. M., 2, 3Protopopov A. I., 2, 3, 4Zabarovsky E. R., 1Rynditch A. V., 1, 2, 3Kashuba V. I.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. Center for Genomics and Bioinformatics,
    Karolinska Institutet
    SE-171 77 Stockholm, Sweden
  3. Department of Microbiology, Tumor and Cell Biology,
    Karolinska Institute
    Nobels vag 5 171 65 Solna, Sweden
  4. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
    32, Vavilova Str., Moscow, Russian Federation, 119991

Abstract

We have identified a novel human gene MLK4. Two alternatively spliced forms of MLK4, named MLKAα and β, have been isolated. The expression of MLK4 has been detected in pancreas, kidney, liver, lung, brain, placenta and heart. The gene has been mapped to chromosomal band lq42. The predicted amino acid sequence of MLK4 is highly related to the amino acid sequence of the members of MLK family, which play an important role in the signal transduction pathways.
Full text: (PDF, in Ukrainian)

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