Biopolym. Cell. 2001; 17(4):298-301.
Structure and Function of Biopolymers
Deletion of the fifth exon of bcr/abl gene by acute lymphoblastic leukosis with Ph'chromosome
- Institute of Molecular Biology and Genetics, NAS of Ukraine
150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
Abstract
Sequencing of 3–8 exons of bcr/abl hybrid gene detected of 5th exon excision (108 nucleotide) in patient with acute lymphoblastic leukosis with breakpoint in M-bcr. Possible role of such disturbance in development oh Ph' leukosis is discussed.
Full text: (PDF, in Ukrainian)
References
[1]
Nowell PC, Hungerford DA. A minute chromosome in human chronic granulocytic leukemia. Science. 1960; 132:1497-9.
[2]
Rowley JD. Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature. 1973;243(5405):290-3.
[3]
Telegeev GD, Dubrovskaya AN, Dybkov MV. Role of BCR/ABL in leukemogenesis. Experimental oncology. 1999; 21 (3-4):182-94.
[4]
Melo JV. The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype. Blood. 1996;88(7):2375-84.
[5]
Gishizky ML. Molecular mechanisms of Bcr-Abl-induced oncogenesis. Cytokines Mol Ther. 1996;2(4):251-61.
[6]
Maurer J, Janssen JW, Thiel E, van Denderen J, Ludwig WD, Aydemir U, Heinze B, Fonatsch C, Harbott J, Reiter A, et al. Detection of chimeric BCR-ABL genes in acute lymphoblastic leukaemia by the polymerase chain reaction. Lancet. 1991;337(8749):1055-8.
[7]
Pane F, Frigeri F, Sindona M, Luciano L, Ferrara F, Cimino R, Meloni G, Saglio G, Salvatore F, Rotoli B. Neutrophilic-chronic myeloid leukemia: a distinct disease with a specific molecular marker (BCR/ABL with C3/A2 junction). Blood. 1996;88(7):2410-4.
[8]
Hochhaus A, Reiter A, Skladny H, Melo JV, Sick C, Berger U, Guo JQ, Arlinghaus RB, Hehlmann R, Goldman JM, Cross NC. A novel BCR-ABL fusion gene (e6a2) in a patient with Philadelphia chromosome-negative chronic myelogenous leukemia. Blood. 1996;88(6):2236-40.
[9]
Negrini M, Tallarico A, Pazzi I, Castagnoli A, Cuneo A, Castoldi GL. A new chromosomal breakpoint in Ph positive, bcr negative chronic myelogenous leukemia. Report of a case. Cancer Genet Cytogenet. 1992;61(1):11-3.
[10]
Suryanarayan K, Hunger SP, Kohler S, Carroll AJ, Crist W, Link MP, Cleary ML. Consistent involvement of the bcr gene by 9;22 breakpoints in pediatric acute leukemias. Blood. 1991;77(2):324-30.
[11]
Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162(1):156-9.
[12]
Telegeev GD, Dybkov MV, Bozhko MV, Tretiak NM, Maliuta SS. Molecular-biology approaches to detection of Philadelphia chromosome in patients with leukemia. Biopolym Cell. 1996; 12(6):63-8.
[13]
Maniatis T, Fritsch EF, Sambrook J. Molecular cloning: a laboratory manual. New York: Cold Spring Harbor Lab, 1982; 545 p.
[14]
Mandel M, Higa A. Calcium-dependent bacteriophage DNA infection. J Mol Biol. 1970;53(1):159-62.
[15]
Birnboim HC, Doly J. A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res. 1979;7(6):1513-23.
[16]
Westbrook CA, Hooberman AL, Spino C, Dodge RK, Larson RA, Davey F, Wurster-Hill DH, Sobol RE, Schiffer C, Bloomfield CD. Clinical significance of the BCR-ABL fusion gene in adult acute lymphoblastic leukemia: a Cancer and Leukemia Group B Study (8762). Blood. 1992;80(12):2983-90.
[17]
Lichty BD, Keating A, Callum J, Yee K, Croxford R, Corpus G, Nwachukwu B, Kim P, Guo J, Kamel-Reid S. Expression of p210 and p190 BCR-ABL due to alternative splicing in chronic myelogenous leukaemia. Br J Haematol. 1998;103(3):711-5.
[18]
Saglio G, Pane F, Gottardi E, Frigeri F, Buonaiuto MR, Guerrasio A, de Micheli D, Parziale A, Fornaci MN, Martinelli G, Salvatore F. Consistent amounts of acute leukemia-associated P190BCR/ABL transcripts are expressed by chronic myelogenous leukemia patients at diagnosis. Blood. 1996;87(3):1075-80.
[19]
van Rhee F, Hochhaus A, Lin F, Melo JV, Goldman JM, Cross NC. p190 BCR-ABL mRNA is expressed at low levels in p210-positive chronic myeloid and acute lymphoblastic leukemias. Blood. 1996;87(12):5213-7.
[20]
McWhirter JR, Wang JY. Effect of Bcr sequences on the cellular function of the Bcr-Abl oncoprotein. Oncogene. 1997;15(14):1625-34.
[21]
Lichty BD, Kamel-Reid S. Exon-skipping in BCR/ABL is induced by ABL exon 2. Biochem J. 2000;348 Pt 1:63-9.
[22]
Lin CL, Bristol LA, Jin L, Dykes-Hoberg M, Crawford T, Clawson L, Rothstein JD. Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis. Neuron. 1998;20(3):589-602.
[23]
Carstens RP, Eaton JV, Krigman HR, Walther PJ, Garcia-Blanco MA. Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer. Oncogene. 1997;15(25):3059-65.
[24]
Noordzij MA, van Steenbrugge GJ, Verkaik NS, Schr?der FH, van der Kwast TH. The prognostic value of CD44 isoforms in prostate cancer patients treated by radical prostatectomy. Clin Cancer Res. 1997;3(5):805-15.
[25]
Saito H, Nakatsuru S, Inazawa J, Nishihira T, Park JG, Nakamura Y. Frequent association of alternative splicing of NER, a nuclear hormone receptor gene in cancer tissues. Oncogene. 1997;14(5):617-21.
[26]
van Dijk MA, Floore AN, Kloppenborg KI, van 't Veer LJ. A functional assay in yeast for the human estrogen receptor displays wild-type and variant estrogen receptor messenger RNAs present in breast carcinoma. Cancer Res. 1997;57(16):3478-85.
[27]
Kim J, Lee K, Pelletier J. The desmoplastic small round cell tumor t(11;22) translocation produces EWS/WT1 isoforms with differing oncogenic properties. Oncogene. 1998;16(15):1973-9.
[28]
Biondi A, Rambaldi A, Rossi V, Elia L, Caslini C, Basso G, Battista R, Barbui T, Mandelli F, Masera G, et al. Detection of ALL-1/AF4 fusion transcript by reverse transcription-polymerase chain reaction for diagnosis and monitoring of acute leukemias with the t(4;11) translocation. Blood. 1993;82(10):2943-7.
[29]
Silliman CC, McGavran L, Wei Q, Miller LA, Li S, Hunger SP. Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides. Leukemia. 1998;12(9):1404-10.
[30]
van der Reijden BA, van Ommen GJ, Hagemeijer A, Breuning MH. Acute myelogenous leukemia: a disorder of gene splicing? Leukemia. 1996;10(2):204-6.
[31]
Costello R, Sainty D, Lecine P, Cusenier A, Mozziconacci MJ, Arnoulet C, Maraninchi D, Gastaut JA, Imbert J, Lafage-Pochitaloff M, Gabert J. Detection of CBFbeta/MYH11 fusion transcripts in acute myeloid leukemia: heterogeneity of cytological and molecular characteristics. Leukemia. 1997;11(5):644-50.
