Biopolym. Cell. 2001; 17(1):5-19.
Reviews
Heavy metals genetic activity in eukaryotic cells
1Macewicz L. L., 1Lukash L. L.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

The article deals with various aspects of some heavy metals damage activity (nickel, chromium, inorganic mercury and lead). Special attention is paid to the issues, connected with the DNA-damaging activity of the mentioned metals (mutagenicity of their ions in different test-systems, damage mechanism, mechanism of ceil and organism protection from heavy metals mutagenicity), but their toxic activity, biochemical activity, ecological aspects are also briefly discussed.

References

[1] Lovkova MYa, Rabinovich AM, Ponimareva SM, Auzun GN. Why do plants treated?. M.: Nauka, 1989. 256 p.
[2] Listov SA, Petrov NV, Arzamascev AP. The content of heavy metals in herbal drugs. Farmatsia. 1990; (2):19-25.
[3] Viytak AA, Khedreyarv KhKh. On the determination of lead in the blood. Occupational Health and prof. pathology in the Estonian SSR. 1984; 11:17-9.
[4] Environmental Health Criteria. Geneva: WHO, 1990; vol 61. 128 p.
[5] Environmental Health Criteria. Geneva: WHO. 1994; vol 116. 144 p.
[6] Dmitriev MT, Ermachenko AB, Litvinenko VG. [Hygienic characteristics of the contamination of atmospheric air by mercury]. Gig Sanit. 1989;(8):71-3.
[7] Domnin SG, Lipatov GYa, Zykova VA, Hristenko PP, Kiseleva AA, Pylev LN. Hygienic assessment of working conditions in the smelting of copper and nickel ores. Issues. hygiene and prof. pathology in non-ferrous and ferrous metallurgy. M, 1987:4-6.
[8] Zatonskaya VM, Lobanov FI, Makarov NV. Certain aspects of the problem of the pollution of the external and internal environment by Lead. Russ Chem Rev. 1981, 50(4):368-79.
[9] Reichrtova E, Takac L, Kramerova J, Vepsko V, Vagner IV. Bioindication environmental pollution waste Nickel Plant. Zh Gig Epidem Mikrobiol Immunol. 1986; 30(4): 375-381.
[10] Environmental health criteria. Geneva: WHO, 1991. V. 108. 383 p.
[11] Kuntsevich NE, Dubrovskaya GI, Tereshenko OP. Influence of ambient air lead to its accumulation in the body and some biochemical parameters. Byelorussia health. 1989;1:52-5.
[12] Nishchiy RA, Bel'guyevskiy OV, Borodin VI. Peculiarities effect on the organism of lead aerosols of different particulate composition. Hygiene issues of production of nonferrous metals in Kazakhstan. Alma-Ata, 1987: 34-36.
[13] Environmental Health Criteria. Geneva: WHO., 1989; vol 58. 112 p.
[14] Korshun MN. The role of the anion in the toxic effect of inorganic mercury-containing compounds. Farmakologiya i toksikologiya. 1988; 23: 106-10.
[15] Sidorenko GI, Itskova I. Nickel. M.: Meditsina, 1980. 171 p.
[16] Zimakova IE, Sinkova VI, Zakharova YaL. Laws of accumulation and distribution of trivalent Cr in rats. Gig Sanit. 1986; (3): 81-3.
[17] Recommended health-based limits in occupational exposure to heavy metals. Geneva: WHO, 1980. 205 p.
[18] Makarchuk YaM, Kruglikova LA, Ysayevskaya LS. Effect of essential oils on the ligand forms of hemoglobin animals with lead intoxication. 3 Ukr. Conf. on medical botany: Proc. K.: Naukova Dumka, 1992. Vol. 1: 94.
[19] Ermachenko AB. [Hygienic evaluation of the distribution and accumulation of mercury in animals after chronic intake from various media]. Gig Sanit. 1987;(6):72-3.
[20] Krylova AYa, Rubtsov AF. On the accumulation of mercury in human organs. Sud med ekspertiza. 1980. 23(4): 35-8.
[21] Korpela H, Loueniva R, Yrj?nheikki E, Kauppila A. Lead and cadmium concentrations in maternal and umbilical cord blood, amniotic fluid, placenta, and amniotic membranes. Am J Obstet Gynecol. 1986;155(5):1086-9.
[22] Trakhtenberg IM, Ivanova LA. [Current concepts of the action of mercury on cell membranes]. Gig Sanit. 1984;(5):59-63.
[23] Wedrychowski A, Schmidt WN, Hnilica LS. The in vivo cross-linking of proteins and DNA by heavy metals. J Biol Chem. 1986;261(7):3370-6.
[24] Jendryczko A, Drozdz M. [Genotoxicity of metal ions]. Wiad Lek. 1987;40(8):549-53.
[25] Steinmetz-Markiewicz A, Smolik R, Ignatowicz L, Chmielarczyk W. [Carcinogenic and immunomodulatory properties of chromium]. Pol Tyg Lek. 1986;41(27):870-3.
[26] Sugden KD, Burris RB, Rogers SJ. An oxygen dependence in chromium mutagenesis. Mutat Res. 1990;244(3):239-44.
[27] Environmental Health Criteria. Geneva: WHO. 1994. Vol. 118. 144 p.
[28] Gatagonova TM. The functional state of the cardiovascular system in workers engaged in the manufacture of lead. Meditsina truda i prom. ekologiya. 1995; (1):15-7.
[29] Pavlovskaia NA. [Lead levels in workers' blood and urine]. Gig Sanit. 1990;(8):42-4.
[30] Shustov VIa, Olkhovskaia AG, Dodina LG, Za?tseva MP, Iniakina SA. [Effect of ultra high frequency electromagnetic waves and lead on the workers' health; phytotherapy of the disorders]. Med Tr Prom Ekol. 1994;(1):21-2.
[31] Angell NF, Lavery JP. The relationship of blood lead levels to obstetric outcome. Am J Obstet Gynecol. 1982;142(1):40-6.
[32] Il'in VB. Elemental chemical composition of plants. Novosibirsk: Nauka, 1985. 128 p.
[33] Kruglikova LA, Makarchuk YaM, Bagatskaya YaS. Volatile terpenoids as stabilizers erythrocyte membrane. 3 Ukr. Conf. on medical botany: Proc. K.: Naukova Dumka. 1992. Vol. 1: 84.
[34] Solomenchuk TM. Arterial hypertension among women worked with lead compounds for a long time. Dopovidi Nats Akad Nauk Ukrainy. 1995; (8):141-3.
[35] Kristensen P, Eilertsen E, Einarsd?ttir E, Haugen A, Skaug V, Ovreb? S. Fertility in mice after prenatal exposure to benzo[a]pyrene and inorganic lead. Environ Health Perspect. 1995;103(6):588-90.
[36] Miszta H, Dabrowski Z. Effect of mercury and combined effect of mercury and dimethylsulphoxide (DMSO) on the activity of acetylcholinesterase (AchE-E.C. 3.1.1.7) of rat lymphocytes during in vitro incubation. Folia Haematol Int Mag Klin Morphol Blutforsch. 1989;116(1):151-5.
[37] Bariliak IR, Byshovets TF, Korshun MN. [Embryo- and gonadotoxicity of various halogenated derivatives of inorganic mercury]. Gig Sanit. 1984;(10):65-7.
[38] Ermachenko LB. Features rationing salt and mercury vapor in the atmosphere and their impact on the generative function of animals. Environmental Health: Proc. rep. Repub. scientific. conf. K, 1986; 100-1.
[39] Ermachenko AB, Sviridova VV. Effect of mercury intoxication on reproductive function of women. III All-Union. Conf. "The endocrine system of the body and the harmful effects of the environment": Proc. rep. L., 1987; 57-8.
[40] Kirillov YuB, Potapov LL, Krovyankov LP, Koptyubenko SA, Korovyakova ES. Small concentrations of mercury and nonspecific resistance of the organism. Factors of cell. and hormonal. immunity in various Fiziol. and pathology. states: Proc. IX Conf. Chelyabinsk, 1988: 58-9.
[41] Bencko K, Wagner V, Wagnerova M, Ondrejcak V. Immunological profiles in workers exposed to occupational exposure to inorganic mercury. Zh Gig Epidemiol Mikrobiol Immunol. 1990; 34(1): 11-9.
[42] Smirnov MI. [Late effects of exposure to hexi- and trivalent chromium in water on the body]. Gig Sanit. 1985;(7):31-2.
[43] Kutashova ZYa, Bulina ML. Effect of chromium on the fetus and newborn. Actual questions of women's health, maternal and newborn. Alma-ata 1989:131-2.
[44] Smirnnov MI. Effect of trivalent and hexavalent chromium on red blood composition when the body of water. Environmental Health. M. 1987.:78-9.
[45] Panchenko NA. [Reorganization of bone marrow cells in tissue culture following treatment with lead acetate]. Arkh Anat Gistol Embriol. 1981;80(1):73-6.
[46] Bucio L, Souza V, Albores A, Sierra A, Ch?vez E, C?rabez A, Guti?rrez-Ruiz MC. Cadmium and mercury toxicity in a human fetal hepatic cell line (WRL-68 cells). Toxicology. 1995;102(3):285-99.
[47] Rossner P, Bencko V, Sram R. The combined effect of chromium and nickel in the fibroblast cell cultures of mice and rats. Zh gig epidemiol mikrobiol immunol. 1981; 25(3): 224-9.
[48] Korshun MYa. Embryotoxicity inorganic mercury-containing compounds. Genetics of congenital malformations. K.: Naukova Dumka, 1986: 78-81.
[49] Govorunova NN, Grin' NV. [Embryotoxic action of nickel-zinc ferrite in body uptake by inhalation]. Gig Sanit. 1984;(5):79-80.
[50] Gorba'n LN, Novichenko NL, Riazanov AV, Cherednichenko VM. [Carcinogenic activity of nickel-containing welding aerosols in relation to their copper and manganese content]. Gig Tr Prof Zabol. 1989;(8):27-31.
[51] Masketi KV, Vysotskiy VD. The activating effect of Cr3 + on the power supply system of the brain. Geriatric means: Exper. Search and wedge usage: Proc. rep. All-Union. Symposium. K., 1990: 119-20.
[52] Iurova AV, Strochkova LS, Zhavoronkov AA. [Ultrastructure of HeLa cella after exposure to nickel ions]. Tsitol Genet. 1988;22(4):13-6.
[53] Ivanitskaya YaF. Processes of free radical oxidation and antioxidant functions of the body in the combined radiation and lead. Probl. radiats. meditsiny. 1992; (4): 109-13.
[54] Farabronkov MG. The functional state of mitochondrial processes with long-term effect of low doses of lead. The emergency management and adaptation under the action of the body extreme. factors. Sverdlovsk, 1984: 40-46.
[55] Antov GP, Ivanovich EKh. [Changes of some enzyme activity in adrenal glands exposed to combined effect of vibration and lead in rats]. Gig Sanit. 1993;(4):55-7.
[56] Yu-Gu L Effects of 13 mutagenes on rat hepatic microsomal enzymes. Cancer of liver, esophagus and nasopharynx. Ed. B. Wagner. Berlin: Springer, 1989: 73-74.
[57] Nazukin AS. [Effects of trivalent chromium on several processes of bioenergetics and adenyl nucleotide metabolism]. Gig Sanit. 1996;(6):39-42.
[58] Sokolov VV, Gribova IA, Ivanova LA. [Cellular and subcellular reactions in studying the effect of low concentrations of toxic substances on the body]. Gig Tr Prof Zabol. 1981;(7):5-8.
[59] Kozlowski H. Donacja siarkowa w ukladach bionieorganicznych. Zezsyty naukowe Uniwersytetu Jagiellonskiego. 1979; l11: 55-63.
[60] Ivanova LA. [Enzyme shifts during chronic exposure to mercury chloride (experimental data on the pathogenesis of mercury poisoning]. Gig Tr Prof Zabol. 1982;(2):27-30.
[61] Ivanitskaia NF. [Evaluation of combined effects of ionizing radiation and mercury on the reproductive function of animals]. Gig Sanit. 1991;(12):48-51.
[62] Sokolovski? VV, Novikova EF, Fedorova VM, Za?tseva NK. [Effect of mercuric ions (II) on ability of blood plasma proteins to bind various forms of ascorbic acid]. Vopr Med Khim. 1983;29(3):96-9.
[63] Chowdhury AR, Vachhrajani KD, Makhija S, Kashyap SK. Histomorphometric and biochemical changes in the testicular tissues of rats treated with mercuric chloride. Biomed Biochim Acta. 1986;45(7):949-56.
[64] Vlasova ME, Gukasov VM, Kaplan BS. The use of the enzyme spectrum of leukocytes and lipid peroxidation of plasma to assess the state of the organism intoxication. Proceedings of the All-Union. Symposium. med enzymology. M., 1986: 171-172.
[65] Cantoni O, Evans RM, Costa M. Similarity in the acute cytotoxic response of mammalian cells to mercury (II) and X-rays: DNA damage and glutathione depletion. Biochem Biophys Res Commun. 1982;108(2):614-9.
[66] Karimov TK. [Vitamin status of workers in the chromium industry]. Vopr Pitan. 1988;(3):20-2.
[67] Iztledov MK, Utenbergenov AA, Kasymbekov VK. The activity of some enzymes erythrocyte and acetylcholine blood when exposed to chromium compounds. Occupational Health, prof. pathology and toxicology in the chemical. industry and non-ferrous. Metallurgy of the Kazakh SSR. Alma-Ata, 1984: 25-29.
[68] Wells TN, Payton MA, Proudfoot AE. Inhibition of phosphomannose isomerase by mercury ions. Biochemistry. 1994;33(24):7641-6.
[69] Venchikov AI. Dosage levels of trace elements and energy processes of the animal organism. Biol. the role of trace elements and their application in agriculture and medicine. M.: Nauka, 1974: 347-350.
[70] Micha?owski D, Wrzesinski J, Krzyzosiak W. Cleavages induced by different metal ions in yeast tRNA(Phe) U59C60 mutants. Biochemistry. 1996;35(33):10727-34.
[71] Semenov VV. [Mutagenesis, antimutagenesis and the cellular regulatory system]. Vestn Ross Akad Med Nauk. 1995;(1):41-4.
[72] Fomenko VN, Glushchenko VI, Katosova LD, Pavlenko GI, Barabanov AA. [Mutagenic and gonadotropic effect of lead]. Gig Tr Prof Zabol. 1982;(10):38-41.
[73] Dzlekanowska D. Badania nad mutagennym wplywem czynnikow srodowiskowych w hutach metali niezelaznych. Pat Pol. 1981; 32(2):263-8.
[74] Azhiev AK. The application of the test for sister chromatid exchanges cytogenetic control conditions chrome production. I All-Union. Congress med. genetics: Proc. M., 1984: 7.
[75] Bigaliev AB. [Chromosome aberrations in a lymphocyte culture from persons in contact with chromium]. Tsitol Genet. 1981;15(6):63-8.
[76] Pashin IuV, Kozachenko VI. [Mutagenic activity of chromium compounds]. Gig Sanit. 1981;(5):46-9.
[77] Deng C, Lee N, Xian H., Yao M, Hong Y. Chromosome aberrations and sister chromatide exchange of peripheral blood lymphocytes in Chinese electropolating workers. Effect of nickel and chromium. J Trace Elements Exp Med. 1988; 1(1): 57-62.
[78] Stella M, Montaldi A, Rossi R, Rossi G, Levis AG. Clastogenic effects of chromium on human lymphocytes in vitro and in vivo. Mutat Res. 1982;101(2):151-64.
[79] Jachimczak D, Skatarczak B. The effects of fluorine and lead ions on the chromosomes of the human leukocytes in vitro. Genet Polon. 1978; 19(3): 353-8.
[80] Bigaliev AB. Genotoxic effects of metal ions. Alma-Ata: Nauka, 1986. 136 p.
[81] Umeda M, Nishimura M. Inducibility of chromosomal aberrations by metal compounds in cultured mammalian cells. Mutat Res. 1979;67(3):221-9.
[82] Bakiev IS. Comparative characteristics of the mutagenic activity of the chromium and nickel in the experiment. Occupational Health and prof. disease in the chemical. industry of Kazakhstan. Alma-Ata, 1987: 165-170.
[83] Sjakste TG, Sjakste NI. Chemical compounds that damage DNA. Riga: Zinatne, 1991. 152 p.
[84] Environmental Health Criteria. Geneva: WHO,, 1991. Vol. 62. 138 p.
[85] Sen P, Costa M. Induction of chromosomal damage in Chinese hamster ovary cells by soluble and particulate nickel compounds: preferential fragmentation of the heterochromatic long arm of the X-chromosome by carcinogenic crystalline NiS particles. Cancer Res. 1985;45(5):2320-5.
[86] Newman SM, Summitt RL, Nunez LJ. Incidence of nickel-induced sister-chromatid exchange. Mutat Res. 1982;101(1):67-75.
[87] Kiseleva AA, Lipatov GIa, Pylev LN, Beresneva OIu. [Determination of potential carcinogenicity of nickel-containing dust using a micronuclear test]. Gig Tr Prof Zabol. 1989;(9):31-2.
[88] Kiseleva AA, Pylev LN, Lipatov GIa. [Relation of the degree of mutagenic activity of nickel-containing dust to the dose and time in the micronucleus test]. Gig Sanit. 1990;(9):71-2.
[89] Morita H, Noda K, Umeda M. Mutagenicities of nickel and cobalt compounds in a mammalian cell line. Mutat Res. Elsevier BV; 1985;147(5):265–6.
[90] Amacher DE, Paillet SC. Induction of trifluorothymidine-resistant mutants by metal ions in L5178Y/TK+/- cells. Mutat Res. 1980;78(3):279-88.
[91] Robison SH, Costa M. The induction of DNA strand breakage by nickel compounds in cultured Chinese hamster ovary cells. Cancer Lett. 1982;15(1):35-40.
[92] Privezentsev KV, Milonova IN, Bezlepkin VG. Evaluation of Cd and Ni toxicity and genotoxicity using algal toxicity test and SOS-chromotest. Usp Sovrem Biol. 1995; 115(6):759-64.
[93] Andronikashvili EL, Esipova NG. [Role of metals in the development of some tumor processes]. Biofizika. 1982;27(6):1022-6.
[94] Soroka VR, Anisimova VYa, Kozlov VA, Korobov VYa. The role of metals in regulating the activity of enzymes of nucleotide metabolism. IV Ukr Biochem. Congress. K.: Naukova Dumka, 1982. Pt. 1: 135-136.
[95] Belyaeva YaYa. Autoradiographic study of DNA synthesis in the endocrine glands in chronic exposure to nickel chloride. 2nd All-Union. Conf. "The endocrine system of the body and harmful environmental factors". L., 1987: 28.
[96] Saychenko SYa, Nadeenko VG, Nikiforova VYa, Kaiin AB. The mechanism for the mutagenic action of metals. Issues. hygiene and prof. pathology in non-ferrous and ferrous metallurgy: Proc. M., 1981. Iss. 3: 62-69.
[97] Krasovski? GN, Charyev OG, L'vova GN, Vasil'eva IM, Zasukhina GD. [Relation between determination of the mutagenicity of lead and establishment of safe levels in water]. Gig Sanit. 1984;(3):15-7.
[98] Maganova NB. [Mutagenic properties if lead entering the body in its plant-biotransformed form]. Vopr Pitan. 1987;(2):53-5.
[99] Dzhokhadze TA, Lezhava TA. [Structural mutations of chromosome mutations induced by heavy metal salts during aging in vivo and in vitro]. Genetika. 1994;30(12):1630-2.
[100] Reutova NV, Shevchenko VA. Mutagenesis effect of two different lead compounds. Genetika. 1991;27(7):1275-9.
[101] Ruposhev AR. Mutagenic effects of heavy metal ions and modification of cytogenetic effect of ethyleneimine: Auth. Thesis. ... kand biol nauk. M., 1986. 25 p.
[102] Kanematsu N, Hara M, Kada T. Rec assay and mutagenicity studies on metal compounds. Mutat Res. 1980;77(2):109-16.
[103] Bondarenko VM. Effect of chromium compounds in the process of transfer and inheritance of chromosomal markers in E. coli II urgency. vopr. Medicine in Kuzbass. Novokuznetsk, 1984: 218-221.
[104] Kustov VV. [The questions of the combined action on the body of industrial chemical compounds and ionizing radiations]. Gig Tr Prof Zabol. 1989;(2):35-9.
[105] Saychenko SP. Experimental evaluation of the genetic hazard of metals when the body with drinking water. Probl. occupational health prof. pathology and toxicology in the mining and metals industry. M., 1985: 75-81.
[106] Andreev VP, Pal'tsyn AA. [Autoradiographic study of DNA synthesis in epithelial cells of albino rat kidney tubules as affected by corrosive sublimate nephrosis]. Biull Eksp Biol Med. 1985;100(11):626-9.
[107] Brambilla G, Martelli A, Marinari UM. Is lipid peroxidation associated with DNA damage? Mutat Res. 1989;214(1):123-7.
[108] Vaca CE, Wilhelm J, Harms-Ringdahl M. Interaction of lipid peroxidation products with DNA. A review. Mutat Res. 1988;195(2):137-49. ttp://
[109] Ehkova GS, Tikhonov YaYa, Sheremet GS. Changes in the content of vitamin E with lead exposure. health of Kazakhstan. 1987; (12): 33-5.
[110] Kolpakova AF. On the exchange of trace elements in nickel production workers. Metabolite aspects of the action on the organism industrial chemical. compounds. Krasnoyarsk, 1982: 119-20.
[111] Khotimchenko SA, Kodentsova VM, Alekseeva IA, Vlaskina SG, Vrzhesinskaia OA, Sokol'nikov AA, Kharitonchik LA, Aleshko-Ozhevski? IP, Sheviakova LV. [Influence of lead on metabolism of vitamins B group in alimentary iron deficient rats]. Vopr Med Khim. 1997;43(3):158-64.
[112] Ilinskih YaYa, Medvedev MA, Bessudnova SS, Ilinskih IYa. Mutagenesis in different functional states of the body. Tomsk, 1990. 228 p.
[113] Kolesnichenko LS, Kulinski? VI, Mantorova NS. [Regulation of various isoenzymes of glutathione transferases of protein kinase A and cAMP]. Ukr Biokhim Zh. 1991;63(2):77-83.
[114] Tiunov LA, Ivanova VA. [Role of glutathione in detoxification processes]. Vestn Akad Med Nauk SSSR. 1988;(1):62-9.
[115] Yoshioka K, Deng T, Cavigelli M, Karin M. Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression. Proc Natl Acad Sci U S A. 1995;92(11):4972-6.
[116] Sr?m RJ. Effect of glutathione S-transferase M1 polymorphisms on biomarkers of exposure and effects. Environ Health Perspect. 1998;106 Suppl 1:231-9.
[117] Ranchialis VP, Bal'chiunene LS. [Paradoxical effects of thiol compounds]. Vestn Ross Akad Med Nauk. 1995;(1):44-9.
[118] Pertsov SS, Balashova TS, Kubatieva AA, Sosnovski? AS, Pirogova GV, Abramov VM. [Lipid peroxidation and antioxidant enzymes in rat brain in acute emotional stress: effect of interleukin-1beta]. Biull Eksp Biol Med. 1995;120(9):244-7.
[119] Ezhkova TS. The effect of lead on the state of the antioxidant status and lipid peroxidation in blood: Auth Thes. ... kand biol nauk. Alma-Ata, 1990..
[120] Aleksperov UK, Mekhti-Zade ER. Physiology regulation mutagenesis. Baku: Elm, 1989. 143 p.
[121] Oleynik SA, Blyum IA. Correction of antioxidant homeostasis guinea pigs antioxidant complex irradiation.Suchasni pytannya klin. ta eksperym. onkolohiyi: Tezy dop. K., 1994: 5.
[122] Stanislavchuk NA, Pentiuk AA, Gorshkov VK, Pentiuk NA. [Effect of thiamine and riboflavin derivatives on the activity of xenobiotic-metabolizing enzyme and on the pharmacologic effect of analgesics]. Vopr Med Khim. 1995;41(5):42-5.
[123] Storozhok NM, Drulle AIa, Login IaIa, Dregeris IaIa, Khrapova NG, Burlakova EB. [Antioxidant activity of natural and synthetic quinones]. Vopr Med Khim. 1995;41(1):16-21.
[124] Geetanjali D, Rita P, Reddy P. Antimutagenic effect of ascorbic acid on sister-chromatide exchanges in human lymphocyte culture. Am J Hum Genet. 1991; 49(4), suppl: 445.
[125] Halliwell B. Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet. 1994;344(8924):721-4.
[126] Anistratenko TI. Hygienic substantiation of nutritional prevention of metabolic processes antioxidant deficiency caused by radiation: Auth Thesis. ... kand med nauk. K., 1994. 20 p.
[127] Artamonova EIu, Sinel'shchikova TA, Zasukhina GD. [Differences in antimutagenic activity of vitamin preparations in human cells under the effect of various types of mutagens]. Genetika. 1994;30(11):1556-7.
[128] Krajcovicova-Kudlackova M, Bobek P, Ozdin L. Effects of cadmium and vitamin E uptake on prooxidative. antioxidative status of rat liver. Biologia. 1995; 50(3): 297-303.
[129] Ziemianski S, Panczenko-Kresowski B, Wartanowicz M, Lapinska-Mucha K. The effect of increased intake of antioxidant vitamins on lipid peroxidation and SOD activity on exercised rats. Zywienie czlowieka i metabolizm. 1996; 23(3): 187-94.
[130] Stearns DM, Kennedy LJ, Courtney KD, Giangrande PH, Phieffer LS, Wetterhahn KE. Reduction of chromium(VI) by ascorbate leads to chromium-DNA binding and DNA strand breaks in vitro. Biochemistry. 1995;34(3):910-9.
[131] Pentiuk AA, Durnev AD, Matvi?chuk NV, Gutsol VI, Iavorski? AN, Shcherbaniuk VV, Seredenin SB. [Vitamin A and enzyme systems of metabolic activation of genotoxic compounds]. Vestn Ross Akad Med Nauk. 1995;(1):3-9.
[132] Stefanov B, Ribarov S, Ka?nakchieva R, Georgieva Ia, Benchev I. [Effect of tocopherol on the hematological indices in lead poisoning]. Gig Sanit. 1982;(8):64-5.
[133] Koterov AN, Trebenok ZA, Pushkareva NB, Nikol'ski? AV. [The diverse effects of the combined action of cadmium chloride and ionizing radiation on the content of metallothioneins in mouse bone marrow and liver]. Radiats Biol Radioecol. 1997;37(2):196-201.
[134] Koterov AN, Kon' IIa. [Antioxidant effect of metallothioneins in acute bromobenzene poisoning in mice]. Ukr Biokhim Zh. 1995;67(5):99-105.
[135] Schwarz MA, Lazo JS, Yalowich JC, Allen WP, Whitmore M, Bergonia HA, Tzeng E, Billiar TR, Robbins PD, Lancaster JR Jr, et al. Metallothionein protects against the cytotoxic and DNA-damaging effects of nitric oxide. Proc Natl Acad Sci U S A. 1995;92(10):4452-6.
[136] Peraza MA, Ayala-Fierro F, Barber DS, Casarez E, Rael LT. Effects of micronutrients on metal toxicity. Environ Health Perspect. 1998;106 Suppl 1:203-16.
[137] Dalton T, Fu K, Enders GC, Palmiter RD, Andrews GK. Analysis of the effects of overexpression of metallothionein-I in transgenic mice on the reproductive toxicology of cadmium. Environ Health Perspect. 1996;104(1):68-76.
[138] Zelger B, Sidoroff A, Hopfl R, Palmiter D, Herold M. Metallothioneine expression in nonmelanoma skin cancer. Appl Immunochem. 1994; 220(4): 254-260.
[139] Koizumi T, Yokota T, Ohmori S, Kumagai H, Suzuki KT. Protective effect of metallothionein on intracellular pH changes induced by cadmium. Toxicology. 1995;95(1-3):11-7.
[140] Gubitskaya EG, Sinelschikova TA, Akhmattulina YaB. Protecting cells from mutagenic interferon. Optimizing the effect. Genet. effects of pollution mutagen factors: Proc. rep. All-Union. coordination. meet. M., 1990: 67-68.
[141] Zasukhina GD, Makedonov GP, Shvetsova TP, Chekova VV, Andronova AV. [Interferons as modifiers of the processes of mutagenesis and reparation]. Zh Obshch Biol. 1986;47(1):42-50.
[142] Vasil'eva IM, Kolonina IV, Kusainova KA, Bogomolova NN, Zasukhina GD. [Mechanisms of disrupting DNA repair in human cells. IV. Interferon protects DNA of noninfected and chronically infected human cells from damage caused by cadmium chloride]. Genetika. 1989;25(10):1872-7.
[143] Bobyleva LA, Chopikashvili LV, Alekhina YaI, Vasileva IM, Zasukhina GD. Reduced pressure mutation workers in contact with heavy metals, using ascorbic acid. Genet. effects of pollution mutagen factors: Proc. rep. All-Union. coordination. meet. M., 1990. C. 51-52.
[144] Korolev AA, Sukhanov BP. [The effect of dietary calcium on the level of body adaptation under conditions of cesium-137 and lead loading]. Vopr Pitan. 1996;(3):34-7.
[145] Bogoslovsyaya OA, Kuhtina EYa, Fedorov YuI, Gluschenko YaYa. Natural antioxidants and antioxidant enzymes when administered to animals transition metals. Yestestv. nauki-zdravookhraneniyu: Tez. dokl. Perm', 1989: 13.
[146] Erzikyan KL, Protasova OV, Maksimova IA, Paschenko LA. Exchange of macro- and microelements in chronic lead intoxication. Zhurn. eksperim. i klinich. meditsiny. 1987; 27(5): 501-504.
[147] Sukhanov BP, Korolev AA, Marninchuk AN, Merzliakova NM. [Experimental study of the protective role of calcium in lead poisoning]. Gig Sanit. 1990;(12):47-9.
[148] Hong YC, Paik SR, Lee HJ, Lee KH, Jang SM. Magnesium inhibits nickel-induced genotoxicity and formation of reactive oxygen. Environ Health Perspect. 1997;105(7):744-8.
[149] Pogribnyy IYa. Effect of selenium on the changes in the activity of antioxidant enzymes in chemical carcinogenesis. V All-Union. biochem. Congress: Abstracts. stand present. M.: Nauka, 1986. Vol. 3: 406-407.
[150] Gromadzi?ska J, Wasowicz W, Sklodowska M, Bulikowski W, Rydzy?ski K. The influence of atmospheric chromium on selenium content and glutathione peroxidase activity in blood of tannery workers. Environ Health Perspect. 1996;104(12):1312-6.
[151] Utschig LM, Bryson JW, O'Halloran TV. Mercury-199 NMR of the metal receptor site in MerR and its protein-DNA complex. Science. 1995;268(5209):380-5.
[152] Aleksandrowicz J, Dobrowolski J. Monitoring komorkowy w odniesieniu do pierwiastkow w zdrowiu i chorobie. Zezsyty naukowe Uniwersytetu Jagiellonskiego. 1990; 11:55-63.