Biopolym. Cell. 2000; 16(5):413-419.
Genome and Its Regulation
Genetic interactions of Delta locus allele with the wing development mutations in Drosophila virilis. 2. Delta and the mutations causing the wing vein excess
1Kozeretskaya I. A., 1Zhuk O. V.
  1. Taras Shevchenko National University of Kyiv
    64, Volodymyrska Str., Kyiv, Ukraine, 01033


In Drosophila viritis neurogenic gene Delta interacts with mutations causing the wing veins excess: Branched and truckee. The basic result of this interaction is the penetrance and expressivity of the mutant Delta phenotype enhancement.


[1] Bray S. A Notch affair. Cell. 1998;93(4):499-503.
[2] Fostier M, Evans DA, Artavanis-Tsakonas S, Baron M. Genetic characterization of the Drosophila melanogaster Suppressor of deltex gene: A regulator of notch signaling. Genetics. 1998;150(4):1477-85.
[3] Micchelli CA, Rulifson EJ, Blair SS. The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate. Development. 1997;124(8):1485-95.
[4] Abu-Issa R, Cavicchi S. Genetic interactions among vestigial, hairy, and Notch suggest a role of vestigial in the differentiation of epidermal and neural cells of the wing and halter of Drosophila melanogaster. J Neurogenet. 1996;10(4):239-46.
[5] Doherty D, Feger G, Younger-Shepherd S, Jan LY, Jan YN. Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation. Genes Dev. 1996;10(4):421-34.
[6] Majumdar A, Nagaraj R, Banerjee U. strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin of Drosophila. Genes Dev. 1997;11(10):1341-53.
[7] Campos-Ortega JA, Knust E. Genetics of early neurogenesis in Drosophila melanogaster. Annu Rev Genet. 1990;24:387-407.
[8] Fleming RJ, Gu Y, Hukriede NA. Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc. Development. 1997;124(15):2973-81.
[9] Diaz-Benjumea FJ, Cohen SM. Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing. Development. 1995;121(12):4215-25.
[10] Murata T, Ogura K, Murakami R, Okano H, Yokoyama KK. hiiragi, a gene essential for wing development in Drosophila melanogaster, affects the Notch cascade. Genes Genet Syst. 1996;71(4):247-54.
[11] Young MW, Wesley CS. Diverse roles for the Notch receptor in the development of D. melanogaster. Perspect Dev Neurobiol. 1997;4(4):345-55.
[12] Muskavitch MA. Delta-notch signaling and Drosophila cell fate choice. Dev Biol. 1994;166(2):415-30.
[13] de Celis JF, Barrio R, del Arco A, Garc?a-Bellido A. Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila. Proc Natl Acad Sci U S A. 1993;90(9):4037-41.
[14] Urbach VY Statistical analysis in biological and medical research. M .: Meditsine, 1975: 135-143.
[15] Gubenko IS, Subbota RP, Kozereretskaia IA, Vagin IuV. The Delta locus in Drosophila virilis: alleles, wing phenotypes and genetic interactions. Tsitol Genet. 1998;32(5):22-34.
[16] Kozeretskaya IA, Zhuk OV. Genetic interactions of Delta lokus allele with the wing development mutations in Drosopfiila virilis. 1. Delta and the mutilions causing the: wing vein reduction. Biopolym Cell. 1999; 15(3):230-6.