Biopolym. Cell. 2000; 16(5):409-412.
Cell Biology
Vitality of cells in culture after combined exposure to heavy metals and radiation
1Dudchenko T. N., 1Lavrenchuk G. I., 1Serkiz Ya. I., 2Zinchenko V. A.
- R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine
45, Vasilkivska Str., Kyiv, Ukraine, 01022 - Institute of Oncology of Academy of Medical Sciences of of Ukraine
Street. University, 33/43, Kiev, Ukraine, 03022
Abstract
Combined influence of middleeffective concentrations of heavy metals (Pb, Ba, Cr, Ni, Cu) and irradiasion by X-rays in LD-50 dose on the indices of vitality of L-cells in culture has been investigated. Kinetic changes of indices are specific for different elements and depend on the level of cellular growth. It was shown that combined exposure to Cr, Pb and radiation on the level of intense cellular growth manifested sinergic or adaptative influence (it decreased growth of cells population, the mitotic index and increased the number of gigantic cells). Cu causes the contrary effect. Pb and Ba increase the mitotic index and the numberof gigantic cells on the stationary growth level.
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