Biopolym. Cell. 2000; 16(4):320-326.
http://dx.doi.org/10.7124/bc.000578
Methods
The interaction of cyanine dyes with nucleic acids. 16. New fluorescent benzothiazole-4-[2,6-dimethylpyridinium] monomethyne cyanine dyes
1Kryvorotenko D. V., 1Kovalska V. B., 1Yarmoluk S. M.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

New fluorescent probes for nucleic acids detection based on 2-[l-(5-carboxypentyl)-2,6-dimethyl-J,4-dihydro-4-pyridinylidenmethyl]-3-methyl-J,3-benzothiazole-3-ium perchlorate have been synthesized. The spectral properties of the compounds obtained and their complexes with nucleic acids have been investigated. The influence of different functional substituents in the dye molecule on its interaction with nucleic acids has been studied. The results obtained show that the inclusion of hydroxy- groups and acridine fragment in the structure of cyanine increases the sensibility of the nucleic acids detection.
Full text: (PDF, in Ukrainian)

References

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