The study of the effect of trimeric 2',5'-oligoadenytic acid (2',5'ApApA) and its epoxyderivative (2',5'-A2(
RAA)) on both human immunodeficiency virus (HIV-1) reproduction and retro-viruses reverse transcriptase activity was conducted. 2',5'-oligo-adenylates were shown to suppress HIV-1 reproduction in case of their pre-incubation with the lymphoblastoid cells of MT-4 line. The possible mechanisms of antivirial action of 2' ,5'-oligoadenylates were under investigation, in particular, the interferonogenic effect of the substances was examined. 2',5'ApApA and 2',5'-A2(
RAA) were shown to increase amounts of interferon in cells two and four-fold respectively compared to control. The inhibitory effect of 2',5'-oligoadenylates on activity of endogenous and exogenous retroviruses reverse transcriptase was demonstrated. The trimeric 2',5'-oligoadenylic acid and its epoxyderivative may be used against HIV infection.
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