Biopolym. Cell. 1999; 15(4):257-261.
Reviews
High selectivity of mutagenic action of synthetic polynucleotides
1Alexandrov Yu. N.
- Institute of Plant Physiology and Genetics, NAS of Ukraine
31/17, Vasylkivska, Kyiv, Ukraine, 03022
Abstract
Solutions of high molecular weight syntetic poiyribo- and polydeoxyribonucleotides of known chemical structure injected into Drosophila melanogaster males caused a 6–17 fold increase of the overall frequency of the recessive lethals in the 2nd chromosome. Complementation analysis of the induced lethals showed an extremely high locus-specificity for some of these mutagens. Possible mechanisms of the mutagenic action of synthetic polynucleotides are discussed.
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