Biopolym. Cell. 1999; 15(2):103-108.
Different models of the diabetes mellitus in experimental research on animals
1Tytok T. G., 1Evseenko A. A., 1Adjamiyan F., 1Kordyum V. A.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680


This review describe the established models of the diabetes in rodents. They mver different forms of the disease concerned with the natural mutations occurred, with genetic engineering manipulations and with the induction using different chemicals agents like as alloksan and streptozotocin (STZ). It was shown that mice response to the subdiabetogemc STZ doses is influenced by animal age. It was also shown the subsequent injection sensibilizes mice response.


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