Biopolym. Cell. 1999; 15(1):83-87.
A possible general mechanism of the signal transfer switching on the α/β-interferons expression. 2. The role of the cAMP in the process of the interferon induction
1Karpov A. V.
  1. D. K. Zabolotny Institute of Microbiology and Virology, NAS of Ukraine
    154, Academika Zabolotnogo Str., Kyiv, Ukraine, 03680


The author carries out an analysis of available data concerning the participation of cyclic adenosine 3',5'-monophosphate (cAMP) in the signal transduction pathway on the α/β-inierferons (IFN) expression during the induction process. The cAMP is known to participate in the activation of protein kinasev during the interferon induction as well as of nuclear factors activating specifically the regulating domains, of IFN genes. The cAMP is thought to be a secondary key messenger mediating the signal, for α/β-lFN induction, the first stage of this induction being the local cell membrane deformation caused by diffirent inducers.


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