Biopolym. Cell. 1999; 15(1):12-17.
Structure and Function of Biopolymers
Some biochemical and cytologic indices at toxic hepatitis
1Bondarenko L. B., 1Bishovetz T. F., 1Saifetdinova G. A.
  1. Institute of Pharmacology and Toxicology of National Medical Academy of Science of Ukraine
    14, Eugene Pottier Str., Kyiv, Ukraine, 03057


In experiments on rats the cytotoxic effects of CCl4 on the mechanism of cells division have been first observed. It was accompanied with changes in 5'-nucleotidase activity and phospho lipid and cholesterol contents in serum and liver cells microsomal fraction during CCl4-induced toxic hepatitis. II was shown that a-tocopherol short-chain derivative (opposite to vitamin E) treatment increased 5'-nucleotidase activity and normalised pliospholipid and cholesterol contents in serum and liver cell microsomal fraction.


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