Biopolym. Cell. 1998; 14(6):561-566.
http://dx.doi.org/10.7124/bc.0004FC
Discussions
A possible general mechanism of the signal transfer switching on the α/β-interferons expression. 1. The local cell membrane deformation as the first induction stage
1Karpov A. V.
  1. D. K. Zabolotny Institute of Microbiology and Virology, NAS of Ukraine
    154, Academika Zabolotnogo Str., Kyiv, Ukraine, 03680

Abstract

A hypothetic mechanism of the external effect of viruses, synthetic polyaniones, double stranded RNAs, and synthetic double-stranded polyribonucleotides upon a cell is explained. This effect is known to be followed by the α-IFN induction. Double-stranded RNAs and polynudeotides inducing such process are thought to change their conformation in an outer ionic perimembrane layer of cells and to induce the specific local, deformation of cell membranes giving a signal for the α/β-IFN induction. In the case of viruses such a membrane deformation appears on the stage of virus penetration into the cell. The α/β-IFN inducers of intercalating nature are proposed to cause the interferonogenesis in vivo forming complexes with exogenic RNA molecules and stabilizing their double-stranded sites with a partial complementarity.
Full text: (PDF, in English)

References

[1] Ho M. Induction and inducers of interferon. Interferon 1. General and applied aspects. Ed. A. Billiau. Amsterdam; New York; Oxford: Elsevier, 1984;79-124.
[2] Marcus PI. Interferon induction by viruses: double-stranded ribonucleic acid as the common proximal inducer molecule. Interferon 3. Mechanisms of production and action. Ed. R. M. Friedman. Amsterdam; New York; Oxford: Elsevier, 1984; 113-75.
[3] Stringfellow DA. Induction of interferon with low molecular weight compounds: fluorenone esters, ethers (tilorone), and pyrimidinones. Methods Enzymol. 1981;78(Pt A):262-84.
[4] Torrence PT, De Clercq E. Interferon induction by nucleic acids: structure-activity relationships. Interferon and their applications. Eds P. E. Came, W. A. Carter.—Berlin: Springer, 1984;371-83.
[5] Vilek J. Interferon production and its regulation. Interferon
[6] Johnston M, Burke DC. Interferon induction by viruses: molecular requirements. Selective Inhibitors of Viral Functions. Ed. W. E. Carter. Cleveland: CRC press, 1973;123—148.
[7] Taylor-Papadimitriou J, Kallos J. Induction of interferon by "Sepharose"-bound poly(I)-poly(C). Nat New Biol. 1973;245(144):143-4.
[8] Pitha PM, Pitha J. Interferon induction site: poly IC on solid substrate carriers. J Gen Virol. 1973;21:31-7.
[9] Kohno S, Shirasawa N, Umino Y, Matsuno T, Kohase M. Binding of polyriboinosinic-polyribocytidylic acid with cultured cells. Arch Virol. 1975;49(2-3):229-37.
[10] Ito Y, Hosaka Y. Component(s) of Sendai virus that can induce interferon in mouse spleen cells. Infect Immun. 1983;39(3):1019-23.
[11] Tiensiwakul P, Khoobyarian N. Adenovirus fiber protein produces synthesis of interferon in mouse spleen and macrophage cultures. Intervirology. 1983;20(1):52-5.
[12] Shu HL. Interfering and interferon-inducing capacity of NDV. II. Relationship between pyrogenic, interfering, and interferon-inducing activities. Arch Gesamte Virusforsch. 1974;46(3-4):191-7.
[13] Colby C, Chamberlin MJ. The specificity of interferon induction in chick embryo cells by helical RNA. Proc Natl Acad Sci U S A. 1969;63(1):160-7.
[14] Agrawal S, Goodchild J, Civeira MP, Thornton AH, Sarin PS, Zamecnik PC. Oligodeoxynucleoside phosphoramidates and phosphorothioates as inhibitors of human immunodeficiency virus. Proc Natl Acad Sci U S A. 1988;85(19):7079-83.
[15] Loke SL, Stein CA, Zhang XH, Mori K, Nakanishi M, Subasinghe C, Cohen JS, Neckers LM. Characterization of oligonucleotide transport into living cells. Proc Natl Acad Sci U S A. 1989;86(10):3474-8.
[16] Yakubov LA, Deeva EA, Zarytova VF, Ivanova EM, Ryte AS, Yurchenko LV, Vlassov VV. Mechanism of oligonucleotide uptake by cells: involvement of specific receptors? Proc Natl Acad Sci U S A. 1989;86(17):6454-8.
[17] Policard A. La surface cellulaire et son microenvironnement; ro?le dans les agre?gations cellulaires. Paris, Masson, 1972. 84 p
[18] Golovanov MV. The analysis of the structure electric double layer of the living cell. Biofizika. 1995;40(2):372-6.
[19] Golovanov MV, Deriagin BV. [The behavior of the plasma membrane and membrane-coating layer (glycocalyx) in a high-concentration electrolyte]. Biull Eksp Biol Med. 1992;114(8):210-2.
[20] Breing MC, Morahan PS. Interferon inducers: polyanions and others. Interferon and interferon inducers. Ed. I) A. Stringfellow. New York: Dekker, 1980;239-61.
[21] Williams RJP. The binding of metal iones to membranes and its consequences. In:. Biological Membranes: Twelve essays on their organization, properties and function. Ed. Parsons DS. Oxford University Press, 1975. : 106-121.
[22] Pulman V, Pulman V, Levori R. Second biologically - code and molecular electrostatic potential in the complaints of nucleic acids. : Current Problems. Physics and Biophysics solid surface: Sb Trudov Ed. VD Bakhtariara. Kiev: Naukova Dumka, 1982:158-67.
[23] Arnott S. The geometry of nucleic acids. Prog Biophys Mol Biol. 1970;21:265-319.
[24] Edy VG, Szekely M, Himmelweit F, Chain EB. Effect of fragmentation on interferon induction by double-stranded virus RNA. J Gen Virol. 1974;23(2):191-5.
[25] Vilner LM, Timkovskiy AL, Tihomirovs-Sidorovi NS. Biological activity and structural features of polynucleotide interferonogens. Virusologiia. M.: VINITI (Itogi nauki i tekhniki, vol. 6), 1977:114-58 (Itogi nauki i tekhniki, vol. 6).
[26] Fasman GD, Lindblow C, Grossman L. The helical conformations of polycytidylic acid: studies on the forces involved. Biochemistry. 1964;3:1015-21.
[27] Chandra P, Zunino F, G?tz A. Bis-deae-fluorenone: A specific inhibitor of DNA polymerases from RNA tumor viruses. FEBS Lett. 1972;22(2):161-4.
[28] Chandra P, Zunino F, Gaur VP, Zaccara A, Woltersdorf M, Luoni G, G?tz A. Mode of tilorone hydrochloride interaction to DNA and polydeoxyribonucleotides. FEBS Lett. 1972;28(1):5-9.
[29] Karpov AV, Zholobak NM. [The interferonogenic properties of yeast RNA-tilorone complexes in a cell culture]. Antibiot Khimioter. 1995;40(5):20-3. Russian.
[30] Karpov AV, Zholobak NM. [Production of type I interferons in the body exposed to yeast RNA-tiloron molecular complexes]. Vopr Virusol. 1996;41(1):13-6. Russian.
[31] Smirnov AV. Specific effects and possible mechanisms of action of exogenous RNA. Usp Sovrem Biol. 1988; 106(1 (4)):20-36.
[32] Wright RG, Wakelin LP, Fieldes A, Acheson RM, Waring MJ. Effects of ring substituents and linker chains on the bifunctional intercalation of diacridines into deoxyribonucleic acid. Biochemistry. 1980;19(25):5825-36.
[33] Marsh M, Helenius A. Virus entry into animal cells. Adv Virus Res. 1989;36:107-51.
[34] Kiriishu UA, Gorava LM. Influence of penetration of the influenza virus in cell ultrastructural reorganization of plasma membranes. Vestci AN Belarusi. Ser. Biol. 1992; (5-6):76-80.
[35] Bukrinskaya AG, Zhdanov VM. Molecular basis of viral pathogenicity. Moscow, Meditsina, 1991: 66—67.
[36] Leonova GN, Ma?strovskaia OS, Chudnovski? VM. [Helium-neon laser radiation as an inducer of interferon formation]. Vopr Virusol. 1994;39(3):119-21. Russian.
[37] Buzhurina MM, Pipov MA.Mechanisms of formation of cellular response external influences. Obshch. probl. fiz.-khim. biologii.M.: VINITI, 1986; 1-258. (Itogi Nauki i tekhniki. Vol. 3)
[38] Olesen SP, Clapham DE, Davies PF. Haemodynamic shear stress activates a K+ current in vascular endothelial cells. Nature. 1988;331(6152):168-70.
[39] Wang N, Butler JP, Ingber DE. Mechanotransduction across the cell surface and through the cytoskeleton. Science. 1993;260(5111):1124-7.
[40] Watson PA. Direct stimulation of adenylate cyclase by mechanical forces in S49 mouse lymphoma cells during hyposmotic swelling. J Biol Chem. 1990;265(12):6569-75.
[41] Pitha PM, Harper HD, Pitha J. Dependence of interferon induction on cell membrane integrity. Virology. 1974;59(1):40-50.
[42] Re?zin FN, Ze?tlenok NA, Chumakov MP. Amino acids and membrane transport in the interferonogenesis system. Usp Sovrem Biol. 1974;78(2):254-72.