Biopolym. Cell. 1998; 14(6):553-558.
Methods
The high scale screening of confounds of the series of isoflavonoids and 4-phenylcoumarins with the use of microorganisms
- Institute of Molecular Biology and Genetics, NAS of Ukraine
150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680 - Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine
1, Murmans'ka Str., Kyiv, Ukraine, 02094 - Taras Shevchenko National University of Kyiv
64, Volodymyrska Str., Kyiv, Ukraine, 01033
Abstract
In order to investigate antimicrobial activity of more then 300 compounds of the series of isoflavonoids and 4-phenylcoumarins Salmonella typhimurium LT.2, Escherichia coli and Candida albicans were used. Two structural chemical fragments 7-(1-R1-2-R2-1-on-ethyl)-O-4-phenylcoumarin and 2-R4-3-R5-6-R2-8-R3-7-R1 O- chromone possessing antibactericidal and anticandidal effects were determined.
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