Biopolym. Cell. 1998; 14(6):529-533.
http://dx.doi.org/10.7124/bc.0004F5
Structure and Function of Biopolymers
Influence of α-tocopherol and its derivative on components of liver cell mitochondria membranes during toxic hepatitis
1Bondarenko L. B., 1Blazhchuk I. S., 1Kovalenko V. N., 2Kuzmenko I. V.
  1. Institute of Pharmacology and Toxicology of National Medical Academy of Science of Ukraine
    14, Eugene Pottier Str., Kyiv, Ukraine, 03057
  2. Palladin Institute of Biochemistry, NAS of Ukraine
    9, Leontovycha Str., Kyiv, Ukraine, 01601

Abstract

In experiments on rats (180–250 g b. w.) influence of α-tocoplierol and its derivative on phospholipids, free, esterified and total cholesterol, DPNH-cytochrome c oxidoreductase (complex 1–111 of respiratory chain) of liver cell mitochondria membranes during toxic hepatitis have been studied. It was shown that α-tocopherol and its shortchain derivative in dose 10 mg/kg b. w. could normalise contents of phospholipids and cholesterol and activity of DPNH-cytochrome c oxidoreductase during this pathology.
Full text: (PDF, in Russian)

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