Biopolym. Cell. 1998; 14(5):389-395.
http://dx.doi.org/10.7124/bc.0004E3
Reviews
The mutation processes resulting to cancer: the role of ALU repeats in genetic instability
1Shvachko L. P.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

ALU repeats is numerous the family of mobile genetic elements or retroelements of human genome. This elements take part in the activity recombination events and often participating in the deletion formation, translocations and fusion genes in cancer. It's shown the ALU transposition and incrising of the ALU transcriptions in cancer as leukemia. ALU repeats have been relationship to genetic rearrangements in number human inheriditary diseases too. At last time it's have been observation about the ability of ALU retroelements to modulate the gene expression. It's assumed the role of ALU elements could be important in the search of the early genetic targets of tumorogenesis.
Full text: (PDF, in Russian)

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