Protection of normal and tumor cells of human against MNNG action with a help of fraction isolated from the extract of Sambucus nigra

Lukash, L. L.; Kastetskaya, K. V.; Sukhorada, Ye. M.; Lylo, V. V.; Manko, V. G.; Ruban, T. A.; Evseenko, A. A.

doi:10.7124/bc.0004AA

Biopolym. Cell. 1997; 13(6):479-483.

http://dx.doi.org/10.7124/bc.0004AA

Cell Biology

Protection of normal and tumor cells of human against MNNG action with a help of fraction isolated from the extract of Sambucus nigra

1Lukash L. L., 1Kastetskaya K. V., 1Sukhorada Ye. M., 1Lylo V. V., 1Manko V. G., 1Ruban T. A., 1Evseenko A. A.

Institute of Molecular Biology and Genetics, NAS of Ukraine
150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

After the complex treatment of normal and tumor cell of human with the alkylating agent (MNNG) and the fractions extracted from medical herb S. nigra cellular viability was changed depending on the experimental conditions. In all cases under tenfold dilution of the source extract and each of the individual fractions and mutagen's concentrations 4–6 μM significant decreasing of the viability of studied cells has been observed. Protection or antitoxic effect has been revealed under hundredfold and bigger diluting both the source solution and a number of the individual fractions. At these conditions cellular viability was increased up to the control level and different respond of normal and tumor cells on complex treatment was registrated.

Full text: (PDF, in Russian)

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