Biopolym. Cell. 1997; 13(2):168-172.
http://dx.doi.org/10.7124/bc.00047A
Molecular Mechanisms of Differentiation
The potential targets of Kupffer cells activity during liver regeneration
1Obolenskaya M. Yu.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

This paper addresses possible causal and kinetic correlations between production of biologically active molecules by Kupffer cells and biochemical events in regenerating liver after partial hepatectomy. The expression and activity of some genes and enzymes were evaluated that are potential targets for regulation by Kupffer cells, e. g. transcriptional factors coded by the nuclear protooncogenes, c-fos and c-myc, a tissue-specific gene P450IIE1 and 2'5'oligo(A) synthetase. The results were compared with data about Kupffer cell activity during regeneration. Kupffer cells manifest their specific activities during transition of hepatocytes from quiescence to the first cell cycle and during the promotion of the last one. After termination of these functions the macrophages themselves enter into a cell cycle. These phenomena indicate a regulatory role of mesenchymal cells in triggering and promoting liver regeneration.
Full text: (PDF, in English)

References

[1] Decker K. Biologically active products of stimulated liver macrophages (Kupffer cells). Eur J Biochem. 1990;192(2):245-61.
[2] Maianskii DN, Shcherbakov VI. Hepatocyte regeneration following Kupffer cell stimulation with prodigiosan. Biull Eksp Biol Med. 1978;86(7):69-71.
[3] Cornell RP. Restriction of gut-derived endotoxin impairs DNA synthesis for liver regeneration. Am J Physiol. 1985;249(5 Pt 2):R563-9.
[4] Katsumoto F, Miyazaki K, Nakayama F. Stimulation of DNA synthesis in hepatocytes by Kupffer cells after partial hepatectomy. Hepatology. 1989;9(3):405-10.
[5] Woodman AC, Selden CA, Hodgson HJ. Partial purification and characterisation of an inhibitor of hepatocyte proliferation derived from nonparenchymal cells after partial hepatectomy. J Cell Physiol. 1992;151(2):405-14.
[6] Kronke M, Schutze S, Scneurich P, Pfizenmaier K. TNF signal transduction and TNF-responsive genes. Tumor Nec­ rosis factor. Eds B. B. Aggarwal, J. Vilcek, K. Dekker. New York; Basel; Hong Kong, 1992: 189-216.
[7] Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem. 1995;270(28):16483-6.
[8] Seth A, Gupta S, Davis RJ. Cell cycle regulation of the c-Myc transcriptional activation domain. Mol Cell Biol. 1993;13(7):4125-36.
[9] Razzak ZA, Loyer P, Fautrel A. et al. Cytokines down-regu­ late expression of cytochromes P-450 from families 1A, 2C and 3A in human hepatocyte cultures. Regulation of liver gene expression in health and disease. Eds S. Woo et al. New York: Cold Spring Harbor Lab., 1993: 68.
[10] Pestka S, Langer JA, Zoon KC, Samuel CE. Interferons and their actions. Annu Rev Biochem. 1987;56:727-77.
[11] Widmann JJ, Fahimi HD. Proliferation of mononuclear phagocytes (Kupffer cells) and endothelial cells in regenerating rat liver. A light and electron microscopic cytochemical study. Am J Pathol. 1975;80(3):349-66.
[12] Obolenskaya MYu, Prima VI, Gerasimova TB, Platonov OM. Partial restriction of genome expression – a component of its work reprogramming in regenerating liver of mammals. Biopolym Cell. 1989; 5(2):79-88.
[13] Etienne-Smekens M, Vandenbussche P, Content J, Dumont JE. (2'-5')Oligoadenylate in rat liver: modulation after partial hepatectomy. Proc Natl Acad Sci U S A. 1983;80(15):4609-13.
[14] Uruvaeva IV, Faktor VM. Interrelation of division and cellular function. Liver resistance to toxic influence of CCL4 after partial hepatectomy. Tsitologia. 1976. 18: 1354-9.
[15] Fausto N, Webber E. Liver regeneration. The Liver Biology and Pathobiology. Eds J. M. Arias, J. L. Boyer, N. Fausto et al. New York: Raven press, 1994: 1059-1084.
[16] Becker FF. Acute glycogenolysis: a major stimulus of autophagocytic activity in rat hepatocytes. 1. Proc Soc Exp Biol Med. 1972;140(4):1170-2.
[17] Obolenskaya MYu, Bernauer H, Tran-Thi T-A, Decker K. Levels of rna for TNF-? and receptors during the prereplicative period of liver regeneration. Biopoly. Cell. 1994; 10(5):68-77.
[18] Satoh M, Adachi K, Suda T, Yamazaki M, Mizuno D. TNF-driven inflammation during mouse liver regeneration after partial hepatectomy and its role in growth regulation of liver. Mol Biother. 1991;3(3):136-47.
[19] Akerman P, Cote P, Yang SQ, McClain C, Nelson S, Bagby GJ, Diehl AM. Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy. Am J Physiol. 1992;263(4 Pt 1):G579-85.
[20] Higashitsuji H, Arii S, Furutani M, Mise M, Monden K, Fujita S, Ishiguro S, Kitao T, Nakamura T, Nakayama H, et al. Expression of cytokine genes during liver regeneration after partial hepatectomy in rats. J Surg Res. 1995;58(3):267-74.
[21] Obolenskaya M, Schulze-Specking A, Plaumann B, Frenzer K, Freudenberg N, Decker K. Nitric oxide production by cells isolated from regenerating rat liver. Biochem Biophys Res Commun. 1994;204(3):1305-11.
[22] Curran RD, Billiar TR, Stuehr DJ, Ochoa JB, Harbrecht BG, Flint SG, Simmons RL. Multiple cytokines are required to induce hepatocyte nitric oxide production and inhibit total protein synthesis. Ann Surg. 1990;212(4):462-9.
[23] Decker K. The regulatory role of prostaglandins in the challenged liver. Lipid Mediators in Health and Diseases. Ed. H. Zor. Freund Publ. House, 1994: 133-7.
[24] Callery MP, Kamei T, Flye MW. Kupffer cell tumor necrosis factor-alpha production is suppressed during liver regeneration. J Surg Res. 1991;50(5):515-9.
[25] Kawada N, Inoue M, Decker K. The construction of stellate cells exposed to sinusoidal cell-derived vasoactive substances. Cells of hepatic sinusoid. Eds E. Wisse, D. L. Knook, K. Wake. New York, 1995: 165-70.
[26] Tamura M, Arakaki N, Tsubouchi H, Takada H, Daikuhara Y. Enhancement of human hepatocyte growth factor production by interleukin-1 alpha and -1 beta and tumor necrosis factor-alpha by fibroblasts in culture. J Biol Chem. 1993;268(11):8140-5.
[27] Andus T, Geiger T, Hirano T, Kishimoto T, Tran-Thi TA, Decker K, Heinrich PC. Regulation of synthesis and secretion of major rat acute-phase proteins by recombinant human interleukin-6 (BSF-2/IL-6) in hepatocyte primary cultures. Eur J Biochem. 1988;173(2):287-93.
[28] Stadler J, Harbrecht BG, Di Silvio M, Curran RD, Jordan ML, Simmons RL, Billiar TR. Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and interleukin-6 by rat Kupffer cells. J Leukoc Biol. 1993;53(2):165-72.