Biopolym. Cell. 1997; 13(1):63-69.
Cell Biology
The antioxidant-genoprotective mechanism of the action of the preparation «Mumiyo-Vitas»
1Levitsky E. L., 1Gubskiy Yu. I., 1Primak R. G., 1Goryushko A. G., 1Marchenko A. N., 1Vistunova I. E.
  1. Institute of Pharmacology and Toxicology of National Medical Academy of Science of Ukraine
    14, Eugene Pottier Str., Kyiv, Ukraine, 03057


The protective effect as regards the liver nuclear chromatin of the drug preparation «Mumiyo-Vitas» in condition of genotoxic action of the chlorophose is revealed. This effect is realized in conditions of profilactic intraperitoneal way of the preparation injection to the experimental animals (thrice-repeated before 36, 24 and 0,5 h the poison in dose 240 mg/kg of the body mass) and related to the antioxidant action as regards the lipids chromatin peroxidation processes. The antioxidant-genoprotective effect of the preparation is more expressed as regards the transcriptionally active chromatin fraction and is correlated to the mortality reduction of the experimental animals. In the realization of this effect mainly the c chromatin phosphatidylcholin lipids and DNA take part in.


[1] Gubsky YuI, Levitsky EL, Primak RG et al. Principles of pharmacological protection of nuclear genome. Liky. 1994;4:15-9.
[2] Levitsky EL, Kholodova YuD, Gubsky YuI, Goryushko AG, Primak RG, Vistunova IE, Sachenko LG. Mechanisms of genoprotective action of steroidal preparation BTK-8L based on phytoecdysteroids at chromatin damage by chlorvos. Ukr Biokhim Zh. 1993;65(6):84-91.
[3] Gubsky YuI, Levitsky EL, Primak RG, Goriushko AG, Lenchevskaya LK, Matushrin VA, Vistunova IE, Sachenko LG. Influence of vitamin E on structural and functional liver chromatin organization during tetrachloromethane damage. Biopolym Cell. 1993; 9(3):27-34.
[4] Chabanny? VN, Levitski? EL, Gubski? IuI, Kholodova IuD, Vistunova IE, Vudmaska MI. [Genoprotective effect of drugs based on ecdysteroids in poisoning of rats with tetrachloromethane and chlorophos]. Ukr Biokhim Zh. 1994;66(5):67-77.
[5] Gubsky YuI, Levitsky EL, Primak RG et al. Antioxidant and geneprotective physiological properties mentally active compounds isolated from Damask roses. Liky. 1995; (6):112-8.
[6] Gubsky YuI, Levitsky EL. Mechanisms of the lipid peroxidation of the liver rats chromatin fractions. Biopolym Cell. 1993; 9(5):34-43.
[7] Levytsky? EL, Gubsky? IuY. [Free radical damage of the nuclear genetic apparatus of cells]. Ukr Biokhim Zh. 1994;66(4):18-30.
[8] Burchynskyy SG, Levitsky EL, Kornienko BG et al. Pharmacological effects and mechanisms of action of the drug "mummy". Liky. 1995; (5):103-14.
[9] Gubsky YuI, Levitsky EL, Primak RG, Goriushko AG, Lenchevskaya LK, Vistunova IE, Sachenko LG. Molecular mechanisms of liver chromatin damage by chlorophose in conditions of verapamil and atropin introduction. Biopolym Cell. 1993; 9(4):32-9.
[10] Mironov VA, Yankovskiy SA. Spectroscopy in organic chemistry. M.: Khimia, 1995. 232 p.
[11] Ashmarin IP, Vasil'yev II, Ambrosov VA. Rapid methods of statistical processing and planning experiments. L. : Izd-vo Leningr. gos univ-ta. 1975; 78 p.
[12] Primak RG, Goriushko AG, Levitsky EL, Gubsky YuI, Novikova SN. Study of conformational characteristics of transcriptionally active and repressed chromatin by means of fluorescent probes. Biopolym Cell. 1994; 10(1):41-6.
[13] Gubskiy YuI, Primak RG, Goryushko AG, Levitsky EL. The study of the components of the rat liver chromatin fractions by fluorescent probing methods. Biopolym. Cell. 1994; 10(6):92-7.
[14] Portnyagina VA, Pochinok VYa, Tarakhovsky ML, Pochinok TV, Vonsyatsky VA, Trinus EP, Aleksandrova AI, Karp VK. Reactions of certain mercaptocompounds with stable diphenylpicrylhydrazyl radical. Ukr Biokhim Zh. 1985;51(11):1203-6.
[15] Levitsky EL, Gubsky YuI, Chabanny VN, Volkov GL, Novikova SN. Biochemical characteristics of the rat liver transcriptionally active and repressed chromatin. Biopolym Cell. 1993; 9(6):13-21.