Biopolym. Cell. 1996; 12(6):82-86.
The tetrahydrofuranylic derivatives of C6 substituted 3,5-dioxo- and 3,5-thioxo-1,2,4-triazines as a structural analogs of azapyrimidine nucleosides
1Palchikovskaya L. I., 1Alexeeva I. V., 1Shalamay A. S.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

Influence of C6-aminoalkyl-, C6-mercaptoalkyl-substitutes of 3,5-dioxo- and 3,5-thioxo-derivatives 1,2,4-triazines on the process of tetrahydrofuranylation has been studied. This study was conducted in the conditions, similar to the one-step reaction of nucleic bases glycosylation. We discovered significant dependence of the regiospecifity of this reaction from electronic nature of substitutes in the 6-position.

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