Biopolym. Cell. 1996; 12(5):50-55.
http://dx.doi.org/10.7124/bc.000449
Nucleoside N-acylation with active derivatives of amino acids
1Yarmoluk S. M., 1Kostenko A. M., 1Kryvorotenko D. V., 2Dubey I. Ya.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine
    1, Murmans'ka Str., Kyiv, Ukraine, 02094

Abstract

Simple procedure for N-acylation ofadenosine guanosine and cytidine by active derivatives of amino acids is proposed. Procedure is based on transient silyt protection ofribose hydroxy groups and consists of 3 steps: (a) silytotion of nucleoside by trimethylchloro-silane, (b) reaction of amino group ofsilylated nucleoside with chloroanhydride or active ester of N-protected amino acid, (c) desilylation of intermediate. The yields of N-amino-acylated nucleosides were about 40–90 %.
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