Biopolym. Cell. 1996; 12(3):34-40.
http://dx.doi.org/10.7124/bc.00042A
Investigation on possibility of gravimetric transducer application for biosensors creation
1Patskovsky S. V., 2Sotdatkin A. P., 2El'skaya A. V.
  1. Taras Shevchenko National University of Kyiv
    64, Volodymyrska Str., Kyiv, Ukraine, 01033
  2. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

Several different approaches using gravimetric transducers based on quartz crystal for development of immu.no and chemo-biosensors are presented. Conditions for oscillation of piezocrystals in liquids are discussed and practical oscillator circuits, which ensure work in high viscosity medium are offered. The resonance method of gravimetrical measurement is shown to be advantageous in solution over the widely used conventional oscillation method. The results of model experiments confirm perspectivity of this method development for immunosensors creation.
Full text: (PDF, in Russian)

References

[1] Guilbault GG. Application of piezoelectric quartz crystal microbalances. New York: Elsevier, 1984. Vol. 7: 8-10.
[2] Janata J, Bezegh A. Chemical sensors. Anal Chem. 1988;60(12):62R-74R.
[3] Schierbaum KD, Gerlach A, Haug M, G?pel W. Selective detection of organic molecules with polymers and supramolecular compounds: application of capacitance, quartz microbalance and calorimetric transducers. Sens Actuators A Phys. 1992;31(1-3):130–7.
[4] Sauerbrey GZ. Use of a quartz vibrator for weighing thin films on a microbalance. Z Phyzik. 1959; 155: 206-10.
[5] Bruckenstein S, Shay M. Mass sensitivity of the crystal microbalance in liguid media. Electrochim Acta. 1985; 2: 295.
[6] Barnes C. Development of quartz crystal oscillators for under-liquid sensing. Sens Actuators A Phys. 1991;29(1):59–69.
[7] Kurosawa S, Kitajima H, Ogawa Y, Muratsugu M, Nemoto E, Kamo N. Resonant frequency of a piezoelectric quartz crystal in contact with solutions. Anal Chim Acta. 1993;274(2):209–17.
[8] Schasfoort RBM, Bergveld P, Kooyman RPH, Greve J. Possibilities and limitations of direct detection of protein charges by means of an immunological field-effect transistor. Anal Chim Acta. 1990;238:323–9.
[9] Bataillard P, Gardies F, Jaffrezic-Renault N, Martelet C, Colin B, Mandrand B. Direct detection of immunospecies by capacitance measurements. Anal Chem. 1988;60(21):2374-9.