Biopolym. Cell. 1996; 12(2):24-28.
http://dx.doi.org/10.7124/bc.00041C
Structure and Function of Biopolymers
Effect of radiation on lipid peroxidation and oxidies of SH-groups membrane proteins
1Dreval' V. I.
  1. Kharkov State University
    4, Sq. Dzerzhinsky, Kharkov, Ukraine, 310077

Abstract

Plasma membrane thymocytes were irradiated with doses of 5–104 Gy. Lipid peroxidation quantity SH-groups in membrane proteins and effects on these processes, by cystamine ionol and ethanol were determined. The results give reason to propose, that motive oflipid peroxidation cause direct influence radiation and interaction lipids with OH•-radicals. Oxidies SH-groups inproteins may be cause of process peroxidation by membrane lipids.
Full text: (PDF, in Russian)

References

[1] Kudryashov YB, Berenfeld BS. Basics of Radiation Biophysics. M. : MGU, 1982. 304 p.
[2] Singer SJ, Nicolson GL. The fluid mosaic model of the structure of cell membranes. Science. 1972;175(4023):720-31.
[3] Dreval' VI, Nazarenko ND. Calcium ion binding by thymocyte plasma membranes. Nauchnye Dokl Vyss Shkoly Biol Nauki. 1991;(1):27-31.
[4] Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193(1):265-75.
[5] Vladimirov YuA, Archakov AI. Lipid peroxidation in biological membranes. M.: Nauka, 1972. 252 p.
[6] Kochetov GA. A practical guide to enzymology. M.: Vyschaya shkola, 1971. 352 p.
[7] Zaks L. Statistical estimation. M.: Statistika, 1976. 598 p.
[8] Polivoda BP, Konev VV, Popov GA. Biophysical aspects of radiation damage to biological membranes. Energoatomizdat, 1990; 160 p.
[9] Wills ED. Mechanisms of lipid peroxide formation in animal tissues. Biochem J. 1966;99(3):667-76.
[10] Molchalina AS. Primary radiobiological processes. M., 1973. 240 p.
[11] Kohn H, Waisel Y, Levitt J. Sulfhydryls-A new factor in frost resistance. V. Direct measurements on proteins and the nature of the change in SH during vernalization of wheat. Protoplasma. 1963;57(1-4):556–68.
[12] Vladimirov VG, Krasilnikov II, Arapov OV. Radioprotectors: structure and function. Kiev: Naukova Dumka, 1989. 264 p.
[13] Chebotarev EE, Baraboj VA, Druzhyna NA, et al. Oxidation processes under the organism gamma-neutron irradiation. Kiev: Naukova Dumka, 1986. 216 p.
[14] Fomenko BS, Akoev IG. Radiation damage to the plasma membrane and the radiation lethal effects on cells Usp Sovrem Biol. 1984;97(1):146-58.
[15] Okada S. Radiation Biochemistry: Cells. Academic Press. 1970. 407 p.
[16] Emanuel' NM, Lyaskovskiy YuN. Inhibition of oxidation of lipids. M.: Pishcheprom, 1961. 359 p.
[17] Dreval' VI, Finashin AV. Effect of cell membrane lipid peroxidation on Ca(2+)-ATPase activity. Biofizika. 1991;36(5):799-801.
[18] Graevskiy EJ. Sulfhydryl groups and radiosensitivity. M.: Atomizdat, 1969. 144 p.
[19] Shtreffer K. Radiation biochemistry. M .: Atomizdat 1972. 200 p.
[20] Timofeev-Resovskiy NV, Savich AV, Schalnov MI. Introduction to molecular radiobiology. M.: Meditsina, 1981. 320 p.
[21] Swallow AJ. Radiation chemistry of organic compounds. pcrgamon press, New York, 1960l 322 p.