Characteristic features of specific fermentative function of thrombin and it\'s connection with the structure

Sereyskaya, A. A.

doi:10.7124/bc.00040D

Biopolym. Cell. 1996; 12(1):5-15.

http://dx.doi.org/10.7124/bc.00040D

Characteristic features of specific fermentative function of thrombin and it's connection with the structure

1Sereyskaya A. A.

Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine
1, Murmans'ka Str., Kyiv, Ukraine, 02094

Abstract

This review deals with thrombin peculiarities responsible for its highly selective and effective action in blood clotting system Role of enzyme additional binding-recognition exosites in interaction with fibrinogen is analyzed. As a result of thrombin-fibrinogen recognition complex formation is supposed some conformational changes to arise that couple exosite with active centre and accelerate the catalytic process.

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