Biopolym. Cell. 1994; 10(3-4):58-62.
http://dx.doi.org/10.7124/bc.0003AE
A methodological approach allowing a faster and easier procedure for identification of ΔF508 in CFTR gene
1Gusak N. M., 1Gorownko N. G., 1Homenko N. L., 1Buzhievskaya T. I.
  1. Kyiv State Institute for Advanced Training of Physicians
    9, Dorohozhytska St., Kyiv, Ukraine, 04112

Abstract

The procedure consisted of two steps (direct amplification of DNA from dried blood spots and identification of mutation with the modified method of diagnostic heteroduplexes) was proposed to test the most common mutation in the cystic fibrosis transmembrane regulator gene (ΔF508). The advantages of this approach for screening of different population groups are discussed. The procedure was used to examine 21 families with positive history of CF.
Full text: (PDF, in Russian)

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