2\',5\'-oligoadenylates effect on certain indexes of immune response

Kozlov, A. V.; Tkachuk, Z. Yu.; Slukvin, I. I.; Tchernyshev, V. P.; Mikhailopoulo, I. A.

doi:10.7124/bc.0003AD

Biopolym. Cell. 1994; 10(3-4):52-57.

http://dx.doi.org/10.7124/bc.0003AD

2',5'-oligoadenylates effect on certain indexes of immune response

1Kozlov A. V., 1Tkachuk Z. Yu., 1Slukvin I. I., 1Tchernyshev V. P., 1Mikhailopoulo I. A.

Institute of Molecular Biology and Genetics, NAS of Ukraine
150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

Immunologic characteristics of different 2',5'-oligoadenylates were studied. It was shown that some core trimers of 2',5'-oligoadenylates have immunostimulative qualities while its epoxy-derivative has expressed immunosupressive character. These effects were obtained both in vitro and in vivo experiments.

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