Biopolym. Cell. 1994; 10(2):57-60.
http://dx.doi.org/10.7124/bc.0003A5
The expression of protooncogenes c-myc and c-fos during the first cell cycle in regenerating rat liver
1Pater L. V., 1Chripunov V. A., 1Kvitnitskaya A. B., 1Prima V. I., 1Obolenskaya M. Yu., 1Platonov O. M.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

The relative amount of transcripts of protooncogenes c-myc and c-fos was detected by hybridization methods in nuclear RNA and poly (A) containing cytoplasmic RNA of hepatocytes during 37 hours after partial hepatectomy. The changes of inRNA concentrations are the same for c-fos and c-myc in the nucleus but are displaced to each other in the cytoplasm. The character of these changes indicate that regulation of expression of the two protooncogenes proceeds both on transcriptional and posttranscriptional levels.
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References

[1] Denhardt DT, Edwards DR, Parfett CL. Gene expression during the mammalian cell cycle. Biochim Biophys Acta. 1986;865(2):83-125.
[2] Hunter T. Cooperation between oncogenes. Cell. 1991;64(2):249-70.
[3] Higgins GM, Anderson RM. Experimental pathology of the liver. I. Restoration of the liver of white rat following partial surgical removal. Arch. Pathol. 1931; 12(2):186-202.
[4] Pater LV, Khripunov VA, Prima VI. Modification of methods for RNA isolation with guanidine thiocyanate and vacuum transfer to membranes improve the possibility to analyze high molecular weight transcripts from animal cells. Biopolym Cell. 1991; 7(1):70-5.
[5] Maniatis T, Fritsch EF, Sambrook J. Molecular cloning: a laboratory manual. New York: Cold Spring Harbor Lab, 1982; 545 p.
[6] Grisham JW. A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver; autoradiography with thymidine-H3. Cancer Res. 1962;22:842-9.
[7] Yepifanova OI, Terskikh VV, Polunovskiy VA Resting cells. Properties and functions in the organism. Moscow, Nauka, 1983; 176 p.
[8] Prima VI, Lisitsa EG, Platonov OM. Features of nuclear genome transcription at early steps of liver regeneration: expression of DNA fractions with different repeating sequence frequencies. Biokhimiia. 1982;47(1):145-52.
[9] Obolenskaya MYu, Prima VI, Gerasimova TB, Platonov OM. Partial restriction of genome expression – a component of its work reprogramming in regenerating liver of mammals. Biopolym Cell. 1989; 5(2):79-88.