Biopolym. Cell. 1985; 1(2):79-86.
http://dx.doi.org/10.7124/bc.000017
Cell Biology
Inhibition of replicative DNA synthesis in nuclei of sea urchin (Strongylocentrotus intermwium) embryo by 2', 3'-dideoxy-3'-aminonucleoside 5'-triphosphates
1Kukhanova M. K., 1Kraevsky A. A., 2Terentieva N. A., 2Rasskazov V. A.
  1. Institute of Molecular Biology, Academy of Sciences of the USSR
    Moscow, USSR
  2. The Pacific Ocean Institute of Bioorganic Chemistry, Academy of Sciences of the USSR,
    Vladivostok, USSR

Abstract

2', 3'-dideoxy-3'-aminonucleoside-5'-triphosphates are shown to be inhibitors of repllcative DNA synthesis in isolated nuclei of sea urchin embryo. These compounds inhibit the fragment Okazaki synthesis. The effect of 2', 3'-dideoxy-3'-aminothymidine 5'-triphosphate and arabinothymidine 5'-triphosphate is reversible when adding the corresponding substrate of DNA synthesis, 2'-deoxy-thymidine-5'-triphosphate.
Full text: (PDF, in Russian)

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